“…(1) (9) Chalcone has been used as an important medium for preparing compounds of therapeutic value, and its use has increased widely in pharmaceutical applications, cosmetics and many other industries (10) ( 11) , it is also used as a drug regimen designed to discover new factors to treat diseases (12) , They are also important media for the preparation of many different active organic compounds such as pyrazoline (13) (14) , β-lactam (15) (16) . Also, interest has increased in the use of Chalcone for the purpose of developing many antibacterial compounds (17) (18) , anti-ulcer, (19) antimicrobial (20) (21) , gave activity against three types of human cancer cells (HepG2) liver, (HCT116) colon, (MCF-7) breast (22) , Chalcone chemistry is still a source of great interest For scientists in the 21st century, a variety of promising drugs were produced, such as antifungals (23) (24) , anti-inflammatory, (25) (26) , antitumor (27) , anti-diabetic (28) (29) , Also among the examples of compounds in which the Chalcone derivative is included is a compound (2) anti-genetic and cytotoxic (30) , a compound (3) anti-inflammatory (32) (31) The first pyrimidine derivative (23) was isolated in the year (1818) and is alloxan by the scientist (Brugnatelli) (33) by oxidation of uric acid and nitric acid. Pyrimidine has three isomers that depend on the positions of the two nitrogen atoms in the hexagonal ring (34) , and they have a structure similar to the pyridine ring in that they contain a hexagonal ring and a nitrogen atom (35) , If the substitution is in position 1,2, it is known as pyridazine, at position 1,3 it is known as pyrimidine, and at position 1,4 it is known as pyrazine (36) (37) .…”