Factors related to the severity of obsessive–compulsive symptoms and their impact on suicide risk in epileptic patients

Guo, Xin; Lin, Weihong; Zhong, Rui; Han, Yujuan; Yu, Jieyang; Yan, Kai-Lin; Zhang, Xinyue; Liang, Jing

doi:10.1016/j.yebeh.2023.109362

Cited by 2 publications

(2 citation statements)

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“…Our review demonstrates that the literature available on this topic is extremely heterogeneous in terms of methodology, population size, type of epilepsy investigated and assessment tools used for evaluating the disorder, with many works even failing to differentiate between psychiatric disorders in general and PDs (38)(39)(40)(41)(42)(43). This last issue seems particularly relevant as the vast majority of the examined studies tend to combine and investigate various psychiatric conditions together (44).…”

Section: Discussionmentioning

confidence: 99%

“…This last issue seems particularly relevant as the vast majority of the examined studies tend to combine and investigate various psychiatric conditions together (44). Conversely, when studies do focus on personality comorbidities, they often center on traits or symptoms rather than formally diagnosed PDs (39)(40)(41). Such methodological inconsistencies present a significant barrier to the comprehensive inclusion of pertinent evidence in our analysis, consequently constraining our capacity to derive meaningful insights regarding the relationship between PDs and epilepsy.…”

Section: Discussionmentioning

confidence: 99%

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Personality disorders in people with epilepsy: a review

Viola,

Bisulli,

Cornaggia

et al. 2024

Front. Psychiatry

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Epileptologists and psychiatrists have long observed a correlation between epilepsy and personality disorders (PDs) in their clinical practice. We conducted a comprehensive PubMed search looking for evidence on PDs in people with epilepsy (PwE). Out of over 600 results obtained without applying any time restriction, we selected only relevant studies (both analytical and descriptive) limited to English, Italian, French and Spanish languages, with a specific focus on PDs, rather than traits or symptoms, thus narrowing our search down to 23 eligible studies. PDs have been investigated in focal epilepsy (predominantly temporal lobe epilepsy - TLE), juvenile myoclonic epilepsy (JME) and psychogenic non-epileptic seizures (PNES), with heterogeneous methodology. Prevalence rates of PDs in focal epilepsy ranged from 18 to 42% in surgical candidates or post-surgical individuals, with Cluster C personality disorders or related traits and symptoms being most common. In JME, prevalence rates ranged from 8 to 23%, with no strong correlation with any specific PDs subtype. In PNES, prevalence rates ranged from 30 to 60%, with a notable association with Cluster B personality disorders, particularly borderline personality disorder. The presence of a PD in PwE, irrespective of subtype, complicates treatment management. However, substantial gaps of knowledge exist concerning the neurobiological substrate, effects of antiseizure medications and epilepsy surgery on concomitant PDs, all of which are indeed potential paths for future research.

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