Factors related to unfavorable outcome in minor ischemic stroke

Ton, Mai Duy; Phuong, Dao Viet; Thom, Vu Thi; Dũng, Nguyễn Tiến; Tho, Pham Quang; Thuan, Le Duc; Nguyen, Thanh N.

doi:10.1016/j.jstrokecerebrovasdis.2023.107203

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…In Vietnam, poor clinical outcome in minor stroke patients is related to initial NIHSS scores, clinical progression with NIHSS scores increasing above 4 in the first 24 hours, and intracranial artery stenosis [ 13 ]. However, the definition of END has not been made clear, and the minor stroke definition NIHSS ≤ 4 seems inappropriate.…”

Section: Introductionmentioning

confidence: 99%

Study protocol: Early neurological deterioration in patients with minor stroke, frequency, predictors, and outcomes in Vietnam single-centre study

Nguyen,

Mai,

Dao

et al. 2024

PLoS ONE

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Early neurological deterioration (END) is progressive neurological deterioration with an increase in NIHSS score of 2 points or more in the first 72 hours from the onset of acute ischemic stroke. END increases the risk of poor clinical outcomes at day 90 of ischemic stroke. We will study the frequency, predictors, and outcomes of patients with END in a case-control study at a comprehensive stroke centre in Vietnam. of the design is a descriptive observational study, longitudinal follow-up of patients with minor stroke hospitalized at the Stroke Center of Bach Mai Hospital from December 1, 2023, to December 1, 2024. Minor stroke patients characterized by NIHSS score ≤ 5 hospitalized within 24 hours of symptom onset will be recruited. The estimated END rate is about 30%, relative accuracy ε = 0.11, 95% reliability, expected 5% of patients lost data or follow-up, and an estimated sample size of 779 patients. This study will help determine the END rate in patients with minor stroke and related factors, thereby building a prognostic model for END. Our study determined the END rate in patients with minor stroke in Vietnam and also proposed risk factors for minor stroke management and treatment.

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Section: Introductionmentioning

confidence: 99%

Study protocol: Early neurological deterioration in patients with minor stroke, frequency, predictors, and outcomes in Vietnam single-centre study

Nguyen,

Mai,

Dao

et al. 2024

PLoS ONE

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Elevated systemic inflammation response index is associated with poor outcomes in minor ischemic stroke

Li,

Zhang,

Chen

et al. 2024

Front. Neurol.

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ObjectivesPatients with minor ischemic stroke (MIS) have substantial disability rates at 90 days. Our study aimed to explore the association between the systemic inflammation response index (SIRI) and 3-month functional outcomes in patients with MIS.MethodsWe conducted a prospective observational study in patients with MIS [defined as a National Institutes of Health Stroke Scale (NIHSS) score of 0–3] admitted within 24 h from symptoms onset. Blood samples for the SIRI measurement were collected on admission. The primary outcome measure was poor outcomes at 90 days (defined as a modified Rankin Scale score of 2–6). Univariate and multivariate logistic analyses were performed to assess the association between the SIRI and the risk of 3-month poor outcomes.ResultsA total of 152 patients with MIS were enrolled, of which 24 cases (15.8%) had poor outcomes at 90 days. The median SIRI level was 1.27 [interquartile range (IQR), 0.77–1.92, ×10^9 /L] on admission. MIS patients with poor outcomes had higher levels of the SIRI than patients with good outcomes (poor outcomes: median, 1.93, IQR: 1.17–3.28, ×10^9 /L; good outcomes: median, 1.21, IQR: 0.71–1.80, ×10^9 /L; p = 0.003). The high SIRI level group (SIRI >1.27 × 10^9 /L) had significantly higher rates of poor outcomes at 90 days (22.4% vs. 9.2%, p = 0.026). After adjusting for age, baseline NIHSS score, prehospital delay, Trial of Org 10,172 in Acute Stroke Treatment (TOAST) classification, and other confounders in multivariate analyses, an elevated SIRI level remained independently associated with an increased risk of poor outcomes in patients with MIS [odds ratio (OR): 1.57, 95% confidence interval (CI): 1.12–2.20; p = 0.010]. Meanwhile, a high level of the SIRI (>1.27 × 10^9/L) was still an independent risk factor for 3-month poor outcomes (OR: 4.80, 95%CI: 1.51–15.29; p = 0.008) in MIS patients.ConclusionDisability at 90 days was common in patients with MIS. An elevated SIRI was associated with poor outcomes in MIS patients. The SIRI might be a promising biomarker candidate that can help identify high-risk MIS patients with poor outcomes for reaching individual therapeutic decisions in clinical trials.

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Factors related to unfavorable outcome in minor ischemic stroke

Cited by 2 publications

References 25 publications

Study protocol: Early neurological deterioration in patients with minor stroke, frequency, predictors, and outcomes in Vietnam single-centre study

Study protocol: Early neurological deterioration in patients with minor stroke, frequency, predictors, and outcomes in Vietnam single-centre study

Elevated systemic inflammation response index is associated with poor outcomes in minor ischemic stroke

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