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Purpose This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia. Methods 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF were surveyed using the EQ-5D-5 L questionnaire. The primary outcomes were utility values at admission, discharge and 1-month post-discharge (1MPD). Secondary outcomes included the visual analogue scores (VAS) and the proportion of patients reporting each EQ-5D-5 L dimension levels. Missing data were imputed using multiple imputation, and generalised linear mixed models were fitted. Results At admission, the unadjusted mean utility values and VAS scores for HFrEF patients in Malaysia were as low as 0.150 ± 0.393 and 38.2 ± 20.8, respectively. After a median hospital stay of 4 days, there was a significant improvement in utility values and VAS scores by 0.510 (95% CI: 0.455–0.564) and 28.8 (95% CI: 25.5–32.1), respectively. The utility value and VAS score at 1-month post-discharge were not significantly different from discharge. The proportion of HFrEF patients reporting problems and severe problems in mobility, self-care, usual activities, and anxiety/depression, pain/discomfort reduced at varying degree from admission to discharge and 1MPD. Conclusion HF is a progressive condition with substantial variation in HRQoL during the disease trajectory. During hospitalisation due to worsening of HF, HFrEF population has unfavourable HRQoL. Rapid and significant HRQoL improvement was observed at discharge, which sustained over one month. The study findings can inform future cost-effectiveness analyses and policies.
Purpose This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia. Methods 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF were surveyed using the EQ-5D-5 L questionnaire. The primary outcomes were utility values at admission, discharge and 1-month post-discharge (1MPD). Secondary outcomes included the visual analogue scores (VAS) and the proportion of patients reporting each EQ-5D-5 L dimension levels. Missing data were imputed using multiple imputation, and generalised linear mixed models were fitted. Results At admission, the unadjusted mean utility values and VAS scores for HFrEF patients in Malaysia were as low as 0.150 ± 0.393 and 38.2 ± 20.8, respectively. After a median hospital stay of 4 days, there was a significant improvement in utility values and VAS scores by 0.510 (95% CI: 0.455–0.564) and 28.8 (95% CI: 25.5–32.1), respectively. The utility value and VAS score at 1-month post-discharge were not significantly different from discharge. The proportion of HFrEF patients reporting problems and severe problems in mobility, self-care, usual activities, and anxiety/depression, pain/discomfort reduced at varying degree from admission to discharge and 1MPD. Conclusion HF is a progressive condition with substantial variation in HRQoL during the disease trajectory. During hospitalisation due to worsening of HF, HFrEF population has unfavourable HRQoL. Rapid and significant HRQoL improvement was observed at discharge, which sustained over one month. The study findings can inform future cost-effectiveness analyses and policies.
Background: Limited understanding exists regarding effective return-to-work strategies for persons participating in cardiac rehabilitation (CR). Objective: The aim of this study was to explore the association between CR completion and employment status at 6- and 18-months post-inclusion in CR within primary healthcare settings in the Central Denmark Region. Methods: A cohort study was conducted using data from a non-randomized clinical controlled trial involving persons with ischemic heart disease attending CR between August 1, 2018, and July 31, 2019, within the working age (18–65 years). Successful CR completion was defined as attending ≥75% of the program. Employment status was assessed at 6- and 18-months post-CR inclusion. Logistic and linear regression models, adjusted for potential confounders, were used for association analysis. Results: The study encompassed 244 participants, of whom 109 completed CR and 135 not. At 6 months’ follow-up, 65.9% of the study population were working, with 47.8% being CR completers and 52,2% non-completers. At 18 months’ follow-up, 69.3% of the participants were working, including 45.0% completers and 55.0% non-completers. Conclusion: The study found no statistically significant differences in employment status between persons who completed CR and those who did not, suggesting limited influence of CR attendance on subsequent employment outcomes.
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