Hunger and food insecurity remained some of the serious challenges facing our world in present time with great concerns from Sub-Saharan Africa especially countries like Nigeria. This study investigates food insecurity (FI), health and environment-related factors, and agricultural commercialization among smallholder farm households. This study was conducted in Southwestern Nigeria utilizing cross-sectional survey data from 352 farm households and employed multi-stage sampling procedure. The household FI levels was determined using food insecurity access scale (HFIAS), crop commercialization index (CCI) was used to compute each household’s CCI (four levels), while ordered logit model was used to analyse factors influencing FI. Health and environment-related factors’ access were assessed across each FI category. The results indicated that about 13% of cassava farm households are non-participant in the marketing of their produce. The findings revealed that less than 20%, 30%. and 40% of households in all four FI categories had access to piped water, improved toilet facilities, and electricity respectively. The ordered logit regression analysis indicated that age, gender, education level, farm experience, nonfarm income, and ownership of motorcycle significantly influencing FI in the study areas. Therefore, this study stressed the implementation of policy actions capable of promoting rural infrastructure development that will lead to increased agricultural production, marketing, and improved quality of life of rural dwellers.