Factors That Impact Evaluation of Left Ventricular Systolic Parameters in Myocardial Perfusion Gated SPECT with 16 Frame and 8 Frame Acquisition Models

Abstract

Objective:Evaluating the effects of heart cavity volume, presence and absence of perfusion defect, gender and type of study (stress and rest) on the difference of systolic parameters of myocardial perfusion scan in 16 and 8 framing gated SPECT imaging.Methods:Cardiac gated SPECT in both 16 and 8 framing simultaneously and both stress and rest phases at one-day protocol was performed for 50 patients. Data have been reconstructed by filter back projection (FBP) method and left ventricular (LV) systolic parameters were calculated by using QGS software. The effect of some factors such as LV cavity volume, presence and absence of perfusion defect, gender and type of study on data difference between 8 and 16 frames were evaluated.Results:The differences in ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) in both stress and rest were statistically significant. Difference in both framing was more in stress for EF and ESV, and was more in rest for EDV. Study type had a significant effect on differences in systolic parameters while gender had a significant effect on differences in EF and ESV in rest between both framings.Conclusion:In conclusion, results of this study revealed that difference of both 16 and 8 frames data in systolic phase were statistically significant and it seems that because of better efficiency of 16 frames, it cannot be replaced by 8 frames. Further well-designed studies are required to verify these findings.

Sixteen-Frame Gated Myocardial Perfusion SPECT as a Surrogate for Equilibrium Radionuclide Angiography in Measurement of Systolic and Diastolic Indices: A Cross-Sectional Study

“…They concluded that variables derived from the 16-frame gated images were suitable for clinical use. 9,12,13 New Knowledge Gained: According to our assessment, the LV diastolic functional indices derived from the 16-frame GMPS can be valuable in the serial follow-up and monitoring of cardiovascular diseases.…”

“…They concluded that variables derived from the 16-frame gated images were suitable for clinical use. 9 12 13…”

“…[9][10][11] Information obtained from GMPS also has a high clinical value. 12 Various studies that compared the 8-and 16-frame gated SPECT in determining the systolic and diastolic parameters of the LV resulting from GMPS showed a higher precision of the 16frame gated images. 9,12,13 In one study, the systolic indices of 8-, 16-, and 32-frame images were compared with the results of ERNA, which showed that the LV ejection fraction (LVEF) obtained from GMPS was underestimated compared with ERNA.…”

Evaluation of myocardial perfusion and function in patients with asymptomatic beta-thalassemia major using myocardial gated single-photon-emission computed tomography

“…Moreover, the association between possible perfusion abnormalities and cardiac iron overload should be investigated in future studies using state-of-the-art technologies like positron-emission tomography-MRI. In addition, for a more accurate assessment of diastolic dysfunction in cardiac gated SPECT for comparison with echocardiography, it is better to use 16 frames per cardiac cycle instead of 8 frames per cardiac cycle,[ 18 ] but it was not done in the present study.…”

“…In addition, for a more accurate assessment of diastolic dysfunction in cardiac gated SPECT for comparison with echocardiography, it is better to use 16 frames per cardiac cycle instead of 8 frames per cardiac cycle, [18] but it was not done in the present study.…”