Factors that impact health-related quality of life in adults with celiac disease: A multicenter study

Abstract

AIM:To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease. METHODS:A multicenter, cross-sectional prospective study was performed in patients with celiac disease w h o c o m p l e t e d t w o H R Q O L q u e s t i o n n a i re s : t h e gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ). RESULTS:Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a glutenfree diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively).Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status. CONCLUSION:In untreated celiac disease, the most important factors that influence patient perception of www.wjgnet.com health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD.

Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain

“…Our results suggest that the HRQL found in the general population of adult celiac subjects may be lower than that observed in patients recruited in a hospital setting, giving rise to the hypothesis that periodic medical check-ups improve the quality in life for these patients by encouraging a stricter compliance with a gluten-free diet. In fact, the correct maintenance of a gluten-free diet has repeatedly been shown to be an independent factor associated with a better quality of life among celiac patients, both in children (31) and adults (19,20,22,32,33). Our study did …”

Recent advances in celiac disease

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Psychosocial aspects of coeliac disease: A cross‐sectional survey of a UK population

“…The chronicity of the condition, the limitations imposed by the need to follow a permanent restrictive diet and the risk of other associated diseases can have a negative impact on health-related quality of life (HRQoL) (Casellas et al, 2008) and psychological well-being (Addolorato et al, 2008).…”