Factors that Influence Adherence to Antiretroviral Treatment in an Urban Population, Jakarta, Indonesia

Weaver, Emma R; Pane, Masdalina; Wandra, Toni; Windiyaningsih, Cicilia; Herlina, .; Samaan, Gina

doi:10.1371/journal.pone.0107543

Cited by 25 publications

(29 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In their study, it is likely that their subjects were enrolled in treatment at very high CD4 counts as well as being better prepared in adherence than those of our study. The importance of high adherence to antiretroviral therapy (ART) for HIV disease is well documented, and poor adherence can result in faster disease progression and ADR as well as increased health care costs and sickness., morbidity, mortality, and heightened risk of secondary HIV transmission [52].…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic and viral predictors of antiretroviral drug resistance among persons living with HIV in a large treatment program in Nigeria

et al. 2020

View full text Add to dashboard Cite

Background: Expanded access to combination antiretroviral therapy (cART) throughout sub-Saharan Africa over the last decade has remarkably improved the prognosis of persons living with HIV (PLWH). However, some PLWH experience virologic rebound after a period of viral suppression, usually followed by selection of drug resistant virus. Determining factors associated with drug resistance can inform patient management and healthcare policies, particularly in resource-limited settings where drug resistance testing is not routine. Methods: A case-control study was conducted using data captured from an electronic medical record in a large treatment program in Nigeria. Cases PLWH receiving cART who developed acquired drug resistance (ADR) and controls were those without ADR between 2004 and 2011. Each case was matched to up to 2 controls by sex, age, and education. Logistic regression was used estimate odds ratios (ORs) and 95% confidence intervals (CIs) for factors associated with ADR. Results: We evaluated 159 cases with ADR and 299 controls without ADR. In a multivariate model, factors associated with ADR included older age (OR = 2.35 [age 30-40 years 95% CI 1.29, 4.27], age 41 + years OR = 2.31 [95% CI 1.11, 4.84], compared to age 17-30), higher education level (secondary OR 2.14 [95% CI 1.1.11-4.13]), compared to primary and tertiary), non-adherence to care (OR = 2.48 [95% CI 1.50-4.00]), longer treatment duration (OR = 1.80 [95% CI 1.37-2.35]), lower CD4 count((OR = 0.95 [95% CI 0.95-0.97]) and higher viral load (OR = 1.97 [95% CI 1.44-2.54]). Conclusions: Understanding these predictors may guide programs in developing interventions to identify patients at risk of developing ADR and implementing prevention strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiologic and viral predictors of antiretroviral drug resistance among persons living with HIV in a large treatment program in Nigeria

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Few studies have evaluated factors that influence ART utilization in Indonesia [25, 26], and none have done so in prisons where many PLH are diagnosed and given a choice about starting ART. Using a structured questionnaire and in-depth interviews, we therefore undertook and present a mixed method assessment of patient medication attitudes in 102 male PLH recruited from two large prisons in Jakarta.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Medication Attitudes on Utilization of Antiretroviral Therapy (ART) in Indonesian Prisons

et al. 2015

View full text Add to dashboard Cite

Negative attitudes toward HIV medications may restrict utilization of antiretroviral therapy (ART) in Indonesian prisons where many people living with HIV (PLH) are diagnosed and first offered ART. This mixed-method study examines the influence of medication attitudes on ART utilization among HIV-infected Indonesian prisoners. Randomly-selected HIV-infected male prisoners (n = 102) completed face-to-face in-depth interviews and structured surveys assessing ART attitudes. Results show that although half of participants utilized ART, a quarter of those meeting ART eligibility guidelines did not. Participants not utilizing ART endorsed greater concerns about ART efficacy, safety, and adverse effects, and more certainty that ART should be deferred in PLH who feel healthy. In multivariate analyses, ART utilization was independently associated with more positive ART attitudes (AOR = 1.09, 95 % CI 1.03–1.16, p = 0.002) and higher internalized HIV stigma (AOR = 1.03, 95 % CI 1.00–1.07, p = 0.016). Social marketing of ART is needed to counteract negative ART attitudes that limit ART utilization among Indonesian prisoners.

show abstract

“…Counseling has previously been found to improve ART adherence in the hospital's HIV patient population 11 . This study explored factors associated with HIV group counseling attendance and found that a number of demographic and clinical factors impact patient participation.…”

Section: Discussionmentioning

confidence: 99%

“…Having an HIV positive family member may reduce isolation and provide an incentive outside oneself to attend counseling 11 .…”

Section: Discussionmentioning

confidence: 99%

Factors influencing HIV group counseling participation at a referral hospital in Jakarta, Indonesia

Pane¹,

Maemun

Bautista

2018

hsji

Self Cite

View full text Add to dashboard Cite

Abstrak Latar Belakang: Beberapa penelitian sebelumnya memperlihatkan bahwa dukungan sosial termasuk Konseling HIV dan dukungan kelompok memiliki efek langsung terhadap kepatuhan pada pengobatan HIV. Faktor yang berpengaruh terhadap partisipasi pada konseling kelompok pasien HIV di Indonesia belum diketahui. Penelitian ini dilakukan untuk mengetahui partisipasi pasien HIV pada konseling kelompok di Rumah Sakit Penyakit Infeksi-Sulianti Saroso, Jakarta Utara. Faktor demografi dan klinis pada pasien HIV diduga berhubungan dengan partisipasi dalam konseling kelompok. Metode: Penelitian ini dilakukan pada bulan Juli – Oktober 2013 menggunakan metode kuantitatif dengan desain studi potong lintang. Pasien HIV yang menggunakan anti retroviral sebanyak 1440 orang diminta kesediannya untuk berpartisipasi pada penelitian ini. Analisis dilakukan menggunakan analisis regresi logistik. Hasil: 709 dari 880 pasien yang mengikuti konseling kelompok telah melengkapi kuesioner dan bersedia menjadi sampel penelitian. Sebagian besar responden adalah laki-laki (71.1%), lulus SMP (84.3%), dan bekerja penuh waktu (51.5%). Stadium klinis mayoritas responden (87.3%) stadium 3 dan 4. Sebagian kecil responden (9.7%) memiliki ko-infeksi hepatitis B atau C, dan 12.7 % memiliki anggota keluarga HIV positif. Sebanyak 272 (38,4%) responden mengikuti konseling kelompok. Umur, waktu kerja, kepuasan terhadap penghasilan, memiliki anggota keluarga dengan HIV positif dan responden yang pernah menggunakan narkoba suntik (IDU) merupakan faktor-faktor yang mempengaruhi partisipasi responden pada konseling kelompok. Kesimpulan: Konseling kelompok harus dikenalkan pada penderita HIV yang sulit dijangkau, termasuk pasien yang lebih tua dan pasien dengan riwayat IDU. Selain itu, penyedia layanan kesehatan harus mempertimbangkan jadwal alternatif untuk pasien yang bekerja penuh waktu dan tidak dapat menghadiri konseling kelompok selama jam kerja. Keywords: HIV, konseling, partisipasi, dukungan, sosial Abstract: Background: Previous studies indicate that social support, including HIV counseling and support groups, have a direct effect on adherence to HIV therapy. Currently, factors of non-participation in HIV counseling in the Indonesian population are unknown. Based on this condition, we performed this study to explore HIV patient in group counseling participation at Prof. Sulianto Saroso Infectious Disease Hospital (RSPI-SS), a national referral hospital in Northern Jakarta in Indonesia. We assessed demographic and clinical factors that are associated with participation in HIV group counseling. Methods: A cross-sectional study was conducted between July and October 2013. 1,440 HIV patients in Jakarta obtaining ART from RSPI-SS were approached to participate in a quantitative survey. Factors associated with group counseling participation were assessed using logistic regression analyses. Results: A total of 709 (80.6%) out of 880 patients in group counseling completed the survey. The most of respondents were male (71.1%), had completed at least secondary school (84.3%), and worked full-time (51.5%). The majority (87.3%) of respondents had advanced disease (clinical stage 3 and 4). A small proportion (9.7%) of patients had hepatitis B or C co-infection, and 12.7 % reported having a family member (partner or child) who was also HIV positive. Only 272 (38,4%) of surveyed patients reported attending HIV group counseling. Five variables were found to be independently associated as factors influencing with participation in HIV group counseling including age, hours worked, income satisfaction, Family member with HIV, and history of Injection Drug User’s (IDU’s). Conclusion: Based on findings, outreach activities promoting HIV group counseling should target patients who are unable or less likely to attend group counseling, including older patients and patients with history of IDU’s. Additionally, health care providers should consider alternative schedules for patients who work full-time and are unable to attend group counseling during work hours. Keywords: HIV, counseling, participation, social, support

show abstract

Factors that Influence Adherence to Antiretroviral Treatment in an Urban Population, Jakarta, Indonesia

Cited by 25 publications

References 21 publications

Epidemiologic and viral predictors of antiretroviral drug resistance among persons living with HIV in a large treatment program in Nigeria

Epidemiologic and viral predictors of antiretroviral drug resistance among persons living with HIV in a large treatment program in Nigeria

The Influence of Medication Attitudes on Utilization of Antiretroviral Therapy (ART) in Indonesian Prisons

Factors influencing HIV group counseling participation at a referral hospital in Jakarta, Indonesia

Contact Info

Product

Resources

About