Factors that Influence Health-Related Quality of Life in Patients with Primary Sclerosing Cholangitis

Cheung, Angela; Patel, Himanshu; Meza-Cardona, Javier; Cino, Maria; Sockalingam, Sanjeev; Hirschfield, Gideon M.

doi:10.1007/s10620-015-4013-1

Cited by 50 publications

(86 citation statements)

References 25 publications

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“…Few reports have already indicated the negative impact of PSC on HRQoL [3,4]. In our previous study, we observed an impairment in quality of life for patients with PSC compared to healthy individuals, and our data highlighted a significant impact of female gender in predicting worse quality of life [2].…”

Section: Discussionsupporting

confidence: 61%

ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis

Kempińska-Podhorodecka

Milkiewicz

Jabłoński

et al. 2017

PLoS ONE

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BackgroundPolymorphisms of vitamin D receptor (VDR) contribute to the pathogenesis of multiple autoimmune conditions.MethodsWe investigated the incidence of VDR polymorphisms (rs1544410-BsmI; rs7975232-ApaI; rs731236-TaqI) in a group of patients with primary sclerosing cholangitis (PSC, n = 275) and in healthy controls (n = 376). Additionally, correlations of the VDR polymorphisms with clinical and biochemical factors of the disease were analysed.ResultsThe genotype and allele distributions of these polymorphisms in PSC patients were similar to those observed in controls. However, the ApaI polymorphism was associated with an impaired health-related quality of life (HRQoL). The generic SF-36 questionnaire showed that the Role-Physical (p = 0.01), Role-Emotional (p = 0.01), Physical Component Summary (p = 0.01) and Mental Component Summary (p = 0.003) scores were significantly affected. Similarly, the disease-specific questionnaires, PBC-40 and PBC-27, demonstrated that carriers of the C allele suffered from more severe Itch (p = 0.03 assessed by PBC-40 and PBC-27), more Fatigue (p = 0.02 assessed by PBC-40 and PBC-27) and Impaired Cognitive Capacity (p = 0.04 and p = 0.03). Correspondingly, individuals who were AA homozygotes (non-carriers of the C allele of ApaI) had higher summary scores for the Physical (p = 0.01) and Mental Components (p = 0.006) measured with SF-36. Moreover, they experienced less itch (p = 0.03) and less Fatigue (p = 0.03) and had better Cognitive Abilities (p = 0.04) as assessed by the PBC-40 and PBC-27 questionnaires. No associations between other VDR polymorphisms and clinical or laboratory findings were made.ConclusionIn summary, this study is the first to show that the ApaI polymorphisms in VDR may exert an effect on disease-related symptoms and quality of life in patients with PSC.

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Section: Discussionsupporting

confidence: 61%

ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis

Kempińska-Podhorodecka

Milkiewicz

Jabłoński

et al. 2017

PLoS ONE

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“…This is in stark contrast to, for example, chronic autoimmune cholestatic diseases which may affect a comparable number of adults. Indeed, HRQoL has been thoroughly investigated in primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) showing that both conditions significantly affect patient well‐being . Everyday clinical experience clearly demonstrates that individuals with AIH also struggle with serious symptoms significantly affecting their well‐being.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune hepatitis exerts a profound, negative effect on health‐related quality of life: A prospective, single‐centre study

Janik

Wunsch

Raszeja‐Wyszomirska

et al. 2018

Liver International

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“…Pruritus with chronic liver disease is a refractory symptom and it reduces the patients’ quality of life (QOL) . However, without enough investigation by physicians and medical personnel, the symptom of pruritus could be missed.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of pruritus in patients with chronic liver disease: A multicenter study

Oeda

Takahashi

Yoshida

et al. 2017

Hepatology Research

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Factors that Influence Health-Related Quality of Life in Patients with Primary Sclerosing Cholangitis

Cited by 50 publications

References 25 publications

ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis

ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis

Autoimmune hepatitis exerts a profound, negative effect on health‐related quality of life: A prospective, single‐centre study

Prevalence of pruritus in patients with chronic liver disease: A multicenter study

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