Objective: Socio-economic status (SES) has been positively associated with physical activity (PA) levels in adolescents. In order to tackle these social inequalities, information is needed about the underlying mechanisms of this association. The present study aimed to investigate the potential mediating role of psychosocial correlates of PA on the relationship between SES and PA in European adolescents. Design: Cross-sectional study testing the mediating role of psychosocial correlates in the SES-PA association using the product-of-coefficients test of MacKinnon. Setting: Ten European cities in nine different countries, the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. Subjects: Adolescents (n 2780) aged 12?5-17?49 years self-reported on PA (moderate-to-vigorous intensity PA and total PA), SES indicators (education of the mother and Family Affluence Scale) and psychosocial correlates of PA (stage of change, attitudes, awareness, modelling, social support, self-efficacy, benefits, barriers and environmental correlates). Results: SES (Family Affluence Scale) was significantly associated with moderateto-vigorous intensity PA. According to single-mediator models, this association was significantly mediated by stage of change (t 5 3?6, P # 0?001), awareness (t 5 2?7, 0?001,P # 0?01), modelling (t 5 4?8, P # 0?001), self-efficacy (t 5 2?5, 0?01,P # 0?05), barriers (t 5 2?7, 0?001,P # 0?01) and environmental (t 5 3?0, y See Appendix for full list of HELENA Study Group members.