Factors that predict cognitive decline in patients with subjective cognitive impairment

Fonseca, Jose Andres Saez; Ducksbury, R; Rodda, Joanne; Whitfield, Tim; Nagaraj, Chitra; Suresh, Kallur; Stevens, Tim; Walker, Zuzana

doi:10.1017/s1041610215000356

Cited by 42 publications

(30 citation statements)

References 28 publications

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“…This suggests that objective decline could be detected in those with SCD if more sensitive neuropsychological tests were applied. Consistent with this possibility, some studies have found that older adults with SCD have subtle changes in episodic memory, psychomotor speed, language or executive functions compared to those without SCD [22, 25–27]; however, these subtle cognitive differences are very difficult to capture at the individual level [28], and potential mediating factors such as mood, personality characteristics, and cognitive reserve were not always ruled out in these studies [22]. Although several neuropsychological tests were used to measure objective cognitive performance in the present study, it is possible that a relationship with SCD may have been observed, even after accounting for the relationship between SCD and symptoms of depression, with more sensitive measures of cognition.…”

Section: Discussionmentioning

confidence: 87%

“…Third, we cannot address the value that SCD may hold in predicting future cognitive decline in this sample due to the cross-sectional nature of this study. Several research studies have observed minimal cross-sectional associations between SCD reporting and cognitive performance [5, 8, 9, 24], while others have consistently found associations between SCD reporting and biomarkers of Alzheimer’s disease and future cognitive decline [25, 31–33], although this is not always the case [34, 35]. Our current results replicate and extend previous cross-sectional findings in non-Hispanic Whites to a group of Hispanic older adults; however, additional research continues to be needed to determine the value of SCD in predicting future cognitive changes in older Hispanics.…”

Section: Discussionmentioning

confidence: 99%

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Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar

Muniz

Espinoza

et al. 2018

JAD

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Subjective cognitive decline (SCD) is common in older adults and may be an early marker of future cognitive decline. Research suggest that SCD is more closely related to concurrent symptoms of depression than to objective cognitive performance in non-Hispanic Whites, but it is unknown whether the associations of SCD, cognition, and depression manifest differently in Hispanic older adults. We examined if SCD is associated with objective cognitive performance or with depression symptoms in 145 Hispanic individuals ages 60 or older referred by community health clinics for screening of cognitive complaints. All participants lived near the U.S.-Mexico border, spoke Spanish only, or were Spanish-English bilingual. Memory-only and global cognitive composites were created from scores on Spanish versions of several neuropsychological tests. The Geriatric Depression Scale (GDS) and a five-item SCD questionnaire developed by our group were also completed. Multiple regression analyses showed no significant associations between SCD and memory or global cognitive composite scores after adjusting for age, sex, education, and GDS score. In contrast, there was a significant association between GDS and SCD after adjusting for age, sex, education, global and memory composite scores. Findings suggest that SCD does not accurately reflect current cognitive status in older Hispanics who present to their primary care physician with cognitive complaints. Clinicians should interpret SCD in this population within the context of information about symptoms of depression. Longitudinal research is needed in older Hispanics to better characterize SCD in this population and to determine if it can predict future cognitive decline.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar

Muniz

Espinoza

et al. 2018

JAD

View full text Add to dashboard Cite

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“…Additional studies might take advantage of those markers, which may be better suited for study within larger samples that allow improved phenotypic (diagnostic) stratification. Furthermore, some clinical data indicates that SCI and MCI could be relatively close transitional states preceding AD515253, which may be reflected as similar brain dynamics in the two diagnoses. Although there were robust statistical associations, the lack of a healthy control group that had not been referred from the memory clinic may have limited the power to detect some MCI- and AD-specific effects.…”

Section: Discussionmentioning

confidence: 99%

Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer’s disease continuum

Córdova‐Palomera

Kaufmann

Persson

et al. 2017

Sci Rep

103

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As findings on the neuropathological and behavioral components of Alzheimer’s disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent developments on theoretical neuroscience indicate that instantaneous patterns of brain connectivity and metastability may be a key mechanism in neural communication underlying cognitive performance. However, the potential significance of these patterns across the AD spectrum remains virtually unexplored. We assessed the clinical sensitivity of static and dynamic functional brain disruptions across the AD spectrum using resting-state fMRI in a sample consisting of AD patients (n = 80) and subjects with either mild (n = 44) or subjective (n = 26) cognitive impairment (MCI, SCI). Spatial maps constituting the nodes in the functional brain network and their associated time-series were estimated using spatial group independent component analysis and dual regression, and whole-brain oscillatory activity was analyzed both globally (metastability) and locally (static and dynamic connectivity). Instantaneous phase metrics showed functional coupling alterations in AD compared to MCI and SCI, both static (putamen, dorsal and default-mode) and dynamic (temporal, frontal-superior and default-mode), along with decreased global metastability. The results suggest that brains of AD patients display altered oscillatory patterns, in agreement with theoretical premises on cognitive dynamics.

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“…Even though individuals with SCD, by definition, perform in the objective “normal” range on standard clinical assessments [2], they may demonstrate subtle clinical changes. For example, a few studies have identified objective weaknesses in memory [13,14] and executive functioning [15,16] in those with SCD. Another study of community-dwelling older adults found that difficulties in everyday functioning were commonly endorsed by participants who had a cognitive complaint [17].…”

Section: Introductionmentioning

confidence: 99%

Objective features of subjective cognitive decline in a United States national database

Kielb

Rogalskı

Weıntraub

et al. 2017

Alzheimer's & Dementia

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INTRODUCTION Functional and cognitive features of subjective cognitive decline (SCD) were identified in a longitudinal database from the National Alzheimer Coordinating Center. METHODS Cognitively normal older adults with (SCD+) and without (SCD-) self-reported memory complaints (N=3915) were compared on 1) baseline Functional Assessment Questionnaire (FAQ) ratings, 2) baseline scores and longitudinal rate of change estimates from nine neuropsychological tests, and 3) final clinical diagnoses. RESULTS SCD+ had higher baseline ratings of functional impairment, reduced episodic memory practice effects and poorer performance on neuropsychological tests of psychomotor speed and language, and higher frequencies of mild cognitive impairment and dementia diagnoses at the end of follow-up compared to the SCD- group. DISCUSSION Subtle clinical features of SCD identified in this large cohort are difficult to detect at the individual level. More sensitive tests are needed to identify those with SCD who are vulnerable to cognitive decline and dementia.

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Factors that predict cognitive decline in patients with subjective cognitive impairment

Abstract: Patients who present with subjective memory complaints and are over the age of 61 years are at high risk of cognitive decline and warrant an in-depth assessment and follow-up.

Cited by 42 publications

References 28 publications

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer’s disease continuum

Objective features of subjective cognitive decline in a United States national database

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