Factors That Predict Survival in Patients With Cirrhosis Considered for Liver Transplantation

Suárez, Marcela Alejandra; Hernández-Perera, Julio César; Robaina, Leslie Ramos; Márquez, Laura; Rapado, Leonel González; Valdes, Marcelo E.; Rivero, Hanoi Hernández; Cuza, Anselmo Abdo; Valdés, Alejandro Roque; Bernal, José Pérez; Bernardos, Á.

doi:10.1016/j.transproceed.2008.08.110

Cited by 15 publications

(6 citation statements)

References 7 publications

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“…The main risk factor for developing HCC is liver cirrhosis [ 1 , 2 ]. HCC occurs at a rate of 1% to 4% per year after cirrhosis is established, underlying approximately 80%-90% of cases worldwide [ 3 , 4 ]. The prevalence rate is 492 cases per million in southern China [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo

Fang

Yin

et al. 2017

Oncotarget

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Evaluating the process and mechanism of fibrogenesis is essential in hepatocellular carcinoma (HCC), especially in hepatocyte transformation and oncogenic signaling. We evaluated the oncogenic role of agrin secreted by platelet-derived growth factor (PDGF)-induced hepatic stellate cell (HSC) in HCC. Cells were co-cultured to investigate the effect of activated HSC on hepatocytes. Liquid chromatography and protein profiling analysis were used to search the distinct proteins secreted in HSC supernatant. Sprague Dawley rats with Diethylnitrosamine (DEN)-induced HCC were used to simulate human liver cancer and sorafenib was administered to investigate its effect on hepatocarcinogenesis. A paired “two-tailed” Student t-test and chi-square tests was used for statistical analysis. PDGF acted as an activator of the HSC and sorafenib inhibits the activation by blocking the combination of PDGF and PDGF receptor. The supernatant of activated HSCs promoted the proliferation, metastasis, and invasion of HL-7702 and SMMC-7721, as well as epithelial-mesenchymal transition (EMT). Agrin found in the HSC supernatant showed the same effect on SMMC-7721 as to the supernatant of activated LX-2. Furthermore, downregulation of agrin by siRNA could decrease the proliferation, metastasis, and invasion of SMMC-7721, and promote MET. Sorafenib prevented DEN-induced hepatocarcinogenesis and could alleviate the liver inflammation and fibrosis. Sorafenib could improve the liver function of Sprague Dawley rats by decreasing the serum levels of ALT and AST. These results demonstrate thatPDGF is an effective activator of HSC and sorafenib could inhibit the activation. In vivo experiment suggested sorafenib could alleviate the hepatocarcinogenesis mediated through agrin secretion and could be potential candidate for treatment of cirrhosis.

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Section: Introductionmentioning

confidence: 99%

Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo

Fang

Yin

et al. 2017

Oncotarget

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“…In recent years, the availability of noninvasive tools has increased the proportion of patients with chronic liver cirrhosis diagnosed at the compensated or decompensated stage [4]–[11]. As one of the noninvasive tools, MR imaging can provide accurate three-dimensional reconstruction images, and then fine anatomic images of each liver lobe or spleen could be obtained even in patients with significant ascites, which could achieve the purpose of accurate measurement of the volumes of liver lobe or spleen [19].…”

Section: Discussionmentioning

confidence: 99%

“…It divides the patients into low (class A), intermediate (class B), and poor (class C) risk within different levels between the least sick and the most advanced patients [2], [3]. The Child-Pugh classification is an independent prognostic factor for survival of cirrhosis patients, and stage C in the Child-Pugh classification is strongly associated with worse survival rates [2]–[4]. In addition, Child-Pugh classification scores must be taken into consideration for adequate evaluation of liver transplantation candidates [4].…”

Section: Introductionmentioning

confidence: 99%

“…The Child-Pugh classification is an independent prognostic factor for survival of cirrhosis patients, and stage C in the Child-Pugh classification is strongly associated with worse survival rates [2]–[4]. In addition, Child-Pugh classification scores must be taken into consideration for adequate evaluation of liver transplantation candidates [4].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Assessment of the Presence and Severity of Cirrhosis in Patients with Hepatitis B Using Right Liver Lobe Volume and Spleen Size Measured at Magnetic Resonance Imaging

Chen

Zhang

et al. 2014

PLoS ONE

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ObjectiveTo determine whether right liver lobe volume (RV) and spleen size measured utilizing magnetic resonance (MR) imaging could identify the presence and severity of cirrhosis in patients with hepatitis B.MethodsTwo hundred and five consecutive patients with clinically confirmed diagnosis of cirrhosis due to hepatitis B and 40 healthy control individuals were enrolled in this study and underwent abdominal triphasic enhanced scans using MR imaging. Spleen maximal width (W), thickness (T) and length (L), together with RV and spleen volume (SV), were measured utilizing MR imaging. Spleen multidimensional index (SI) was obtained by multiplying previously acquired parameters W×T×L. Then statistical assessment was performed to evaluate the ability of these parameters, including RV, SV, RV/SV and SI, to identify the presence of cirrhosis and define Child-Pugh class of this disease.ResultsSV and SI tended to increase (r = 0.557 and 0.622, respectively; all P<0.001), and RV and RV/SV tended to decrease (r = −0.749 and −0.699, respectively; all P<0.001) with increasing Child-Pugh class of cirrhosis. All the parameters, including RV, SV, RV/SV and SI, might be the indicators used to discriminate the patients with liver cirrhosis from the control group, and to distinguish these patients between Child-Pugh class A and B, between B and C, and between A and C (area under receiver operating characteristic curve [AUC] = 0.609–0.975, all P<0.05). Among these parameters, RV/SV was the best noninvasive factor for the discrimination of liver cirrhosis between Child-Pugh class A and B (AUC = 0.725), between A and C (AUC = 0.975), and between B and C (AUC = 0.876), while SI was the best variable to distinguish the cirrhosis patients from the control group (AUC = 0.960, P<0.05).ConclusionRV/SV should be used to identify the severity of cirrhosis, while SI can be recommended to determine the presence of this disease.

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“…PT is the most sensitive test for detecting a deficiency of these factors [7], so PT is widely utilized for evaluation of liver disease severity. PT is used in all prognostic models of survival, the classification of CHILD--Pugh or Meld, guidelines for liver biopsies and steroid therapy in alcoholic hepatitis, and is a key criteria for making transplant decision [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Comparison of modes of prothrombin time reporting in patients with advanced liver disease associated with viral hepatitis

Wei¹,

Zheng²,

Xiao³

et al. 2009

J Thromb Thrombolysis

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Factors That Predict Survival in Patients With Cirrhosis Considered for Liver Transplantation

Cited by 15 publications

References 7 publications

Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo

Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo

Quantitative Assessment of the Presence and Severity of Cirrhosis in Patients with Hepatitis B Using Right Liver Lobe Volume and Spleen Size Measured at Magnetic Resonance Imaging

Comparison of modes of prothrombin time reporting in patients with advanced liver disease associated with viral hepatitis

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