This study aimed to investigate the acute specific physiological effects of 15 min of whole-body vibration (WBV) exposure at six different types of vibrations on cardiorespiratory function in 26 healthy young subjects (sex ratio, 1:1; mean age, 20.73 years). The protocols included six variants of a combination of mechanical stimuli with different frequencies (15, 25, and 35 Hz) and direction of stimuli (vertical or diagonal). The investigated cardiorespiratory parameters were heart rate (HR), arterial oxygen saturation (SaO2), respiratory rate (RR), and spirometric indicators: tidal volume (TV), vital capacity (VC), forced vital capacity (FVC), forced expiratory volume at 1 s (FEV1), and maximum voluntary ventilation for 12 s (MVV). The data series were statistically processed by using descriptive and inferential statistical methods: the Shapiro–Wilk test, the two-way ANOVA with repeated measures, and post hoc analysis. We obtained significantly higher values for HR, TV, VC, FVC, FEV1, and MVV after the WBV exposure. These parameters are significantly influenced by both the frequency and direction of stimuli, and certain protocols of WBV are noticeable for their distinct effects. Our results offer a new perspective on the possibility of using preferential variants of vibratory stimulation to obtain maximum cardiorespiratory physiological effects.