In today's health care environment, a contrasting scenario emerges: the advancements of modern medicine provide patients with numerous treatment options, yet at times, simplicity proves more effective. This idea lies at the heart of de-prescribing in contemporary medicine. Whilst various definitions of de-prescribing have been proposed, it is agreed to involve the planned and supervised discontinuing or tapering of medications that are judged to be inappropriate. 1,2 This initiative finds its roots in primary care where the established therapeutic relationship between patient and physician provides an essential backdrop for holistic, generalist health assessments, and proactive, preventative care. 3 The importance of de-prescribing becomes even more pronounced in the elderly population. 1 As people age, they often accumulate numerous medications, each prescribed for a specific ailment or risk. Polypharmacy, defined as concurrent use of five or more medications, has been associated with adverse drug reactions, poorer adherence, increased health care costs, falls, and reduced quality of life. Elderly patients, due to physiological changes, are especially vulnerable to the harms of inappropriate medications. 4 There is also the challenge of drug-drug interactions, which can lead to diminished therapeutic benefits or even new issues. In such contexts, the line between benefit and harm blurs, prompting a need for re-evaluation. 5 Yet, the process of de-prescribing is fraught with uncertainty. Some physicians may encounter de-prescribing as an ethical dilemma, being ingrained with the duty to alleviate suffering and provide care, and finding it counterintuitive to stop a medication. Does stopping a medication signify a withdrawal of care? Or does it represent an evolved understanding of care, one that prioritises the patient's holistic well-being?From a clinical standpoint, the complexities surrounding the decision to de-prescribe often wade into uncharted waters. 6 Consider a scenario where a patient, having been on a specific medication for many years, presents no overt side effects. However, the tangible benefits of this medication are ambiguous at best. Such cases provoke the question: is discontinuing this medication warranted? Furthermore, the decision making process becomes complicated by the inherent variability of patient responses to medications. 7 Whilst one patient might thrive without a certain medication, another might deteriorate, complicating predications about clinical outcomes. Beyond this, a clinician must also seek to understand and negotiate the patient's beliefs and values about their health, and must seek to collaborate with the patient on a decision. Each decision becomes a balance, and clinicians are often left navigating this challenging equilibrium, drawing on both their clinical expertise and their understanding of individual patient priorities.Uncertainty is greatly compounded for clinicians by the lack of evidence-based guidelines for de-prescribing, or even data on the outcomes of de-pres...