2024
DOI: 10.1158/1078-0432.ccr-23-1160
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Facts and Hopes on Chimeric Cytokine Agents for Cancer Immunotherapy

Zhenhua Ren,
Xuhao Zhang,
Yang-Xin Fu

Abstract: Cytokines are key mediators of immune responses that can modulate the antitumor activity of immune cells. Cytokines have been explored as a promising cancer immunotherapy. However, there are several challenges to cytokine therapy, especially a lack of tumor targeting, resulting in high toxicity and limited efficacy. To overcome these limitations, novel approaches have been developed to engineer cytokines with improved properties, such as chimeric cytokines. Chimeric cytokines are fusion proteins that combine d… Show more

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Cited by 4 publications
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