Design is critical in online learning. This chapter reviews research and practice on designing effective online courses in higher education. Firstly, the importance of design in online learning is described including asynchronous, synchronous, and bichronous delivery methods, as well as the significance of course organization and meeting learner needs in online courses. Secondly, we provide a brief overview of online course design research in higher education. Thirdly, standards and rubrics for online course design from US colleges and universities as well as professional organizations across the world are reviewed. Fourthly, we describe a research-based and validated online course design element rubric, which includes overview, course presentation, interaction and communication, assessment and evaluation, and student support. Fifthly, the chapter describes how instructors can be prepared for and supported in online course design, incorporating administrator support, pedagogical support, technology support, and personnel support. Sixthly, the role of instructional designers in online course design is described. The chapter concludes with recommendations for instructors and designers and topics for future research.