This paper analyzes the personal career planning of teachers in higher education institutions, the influencing mechanisms, and the influencing factors. A systematic GMM model was constructed by combining differential GMM estimation and horizontal GMM estimation, and the systematic GMM estimation commonly used in dynamic panels was improved and applied using more effective instrumental variables and continuously updated objective functions. The results of the GMM analysis obtained through the selection of the influencing factors showed that the proportion of senior teachers’ willingness to personal career development and planning decreased by -0.04 and 0.02, respectively, and the proportion of negative development to total development willingness increased by +0.02 and +0.01, respectively, and the proportion of positive development to total development willingness increased by +0.03 and +0.01, respectively, and all of them were significant at the 1% level.