Faecal calprotectin concentrations and diagnosis of necrotising enterocolitis

Carroll, Daniel; Corfield, Anthony P.; Spicer, R. D.; Cairns, Pamela

doi:10.1016/s0140-6736(03)12333-1

Cited by 104 publications

(98 citation statements)

References 4 publications

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“…9 In another study done by Albanna et al showed that they had a mean GA of 32 weeks, a mean birth weight of 1500 gm and a mean age at diagnosis of 9 days. 10 The study of Carroll et al 11 had a mean GA of 30 weeks and mean age at diagnosis of 12 days. In the study of Yang et al mean GA was found 26.6±2.1 weeks and mean birth weight was 982.1±289.4 gm.…”

Section: Discussionmentioning

confidence: 99%

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Islam

Begum²,

Yasmeen³

et al. 2017

Northern Int. Med. Coll. J.

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Background : Premature infants frequently suffer from feeding intolerance and is highly associated to morbidity and mortality. It is a great challenge which have to face all the neonatologist. Feeding intolerance can be defined by difficulty in ingestion or digestion of the milk that causes a disruption in the enteral feeding plan due to the manifestation of some clinical symptoms. These symptoms include gastric residuals, emesis, abdominal distention, visible bowel loops, and change in the character of stool etc.

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Section: Discussionmentioning

confidence: 99%

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Islam

Begum²,

Yasmeen³

et al. 2017

Northern Int. Med. Coll. J.

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“…Elevated concentrations of fecal calprotectin are found in patients with colorectal cancer, inflammatory bowel disease, bacterial infections of the gastrointestinal tract and after treatment with nonsteroidal antiinflammatory drugs (20 -22). It is a simple noninvasive marker to evaluate the inflammatory status of the gastrointestinal tract of neonates, particularly of those at risk of necrotizing enterocolitis, preterm infants, and infants with intrauterine growth retardation (23). Few studies have looked at the fecal calprotectin levels in preterm infants (24 -26), but none of them examined the effect of probiotic supplementation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Bifidobacterium lactis Bb12 Supplementation on Body Weight, Fecal pH, Acetate, Lactate, Calprotectin, and IgA in Preterm Infants

et al. 2008

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Preterm infants are prone to abnormal bacterial colonization of the intestine with ensuing adverse health effects. To examine whether the oral application of Bifidobacterium lactis Bb12 (probiotic) may improve selected indicators of health status in preterm infants, a double blind, placebo controlled randomized clinical study was performed on 69 preterm infants (Ͻ37 gestation wk). Weight gain was defined as the primary outcome measure. In antibiotic-treated infants, probiotic supplementation resulted in a higher body weight compared with placebo (p Ͻ 0.001). In the probiotic group, the fecal pH was significantly lower than in the placebo group. The fecal concentrations of acetate and lactate were 42 and 38% higher, respectively, in the probiotic group than in the placebo group.

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“…Increased calprotectin levels have been detected in intestinal diseases associated with inflammation such as necrotizing enterocolitis, and its quantitation provides a measure of the degree of tissue inflammation in adults with irritable bowel disease (31,32). Neopterin and calprotectin appears to play a regulatory role in the inflammatory process as well as calprotectin (33,34).…”

Section: Bowel Inflammation In Gastroschisismentioning

confidence: 99%

Biochemical Investigations of Bowel Inflammation in Gastroschisis

et al. 2006

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ABSTRACT:Neonates with gastroschisis have perivisceritis resulting from contact between the bowel and amniotic fluid. Here, we characterized the mediators involved in this inflammatory process in humans and ewes, to find a reliable marker of this process. We have diagnosed 41 cases of gastroschisis since 1995. Amniotic fluid sampled for karyotyping between 15 and 32 wk of gestation was also used to assay cytokines and inflammatory proteins. The findings were compared with those in 93 age-matched controls. Amniotic fluid cells were analyzed by means of cytology. Histologic examination of the bowel was performed when neonatal appendectomy was performed. The findings were compared with those obtained in a ewe model of gastroschisis. In gastroschisis, amniotic total protein, IL-6, IL-8, and ferritin levels were significantly higher than in controls. Gastroschisis was associated with significantly higher cell counts (mainly mononuclear cells) in amniotic fluid. At birth, macrophages were abundant in the fibrous peel covering the bowel. Similar results were obtained in the ewe model. Gastroschisis may be associated with a subchronic inflammatory process of variable intensity. This inflammation is restricted to the bowel wall and involves inflammatory cells such as macrophages, which may secrete ferritin, neopterin, and calprotectin. G astroschisis is an abdominal wall defect in which various segments of the bowel extrude through a small paraumbilical defect, usually situated on the right side. Prenatal diagnosis is usually made in the second trimester, when sonography shows bowel loops floating freely in amniotic fluid (1). Gastroschisis is rare (1/6000 to 1/10,000 pregnancies) and generally isolated. Its cause is unknown, but probably involves premature regression of the omphalomesenteric artery, leading to failure of the mesodermal components of the abdominal wall (2). The survival rate exceeds 90%. Factors of poor prognosis include intrauterine growth retardation, oligohydramnios, and the degree of perivisceritis at birth (3).Perivisceritis in this setting is due to aseptic peritonitis, probably secondary to prolonged exposure of the bowel to amniotic fluid (4). The components of amniotic fluid involved in this reaction are controversial, but we have previously obtained evidence incriminating high levels of digestive enzymes, which may aggress the gut; this is also supported by experimental findings (5,6). The inflammatory process includes edema, fibrin deposition, and cell infiltration of the bowel wall (7,8). We and Morrison et al. (9,10) have shown on restricted studies that the degree of inflammation should be used to evaluate gut damage. Here we studied a series of human cases of gastroschisis and used a ewe experimental model to examine the involvement of inflammatory cells and soluble mediators. MATERIALS AND METHODSPatients and samples. Forty-one human pregnancies complicated by fetal gastroschisis have been managed at Robert Debré Hospital since 1995. Gastroschisis was diagnosed between 15 and 32 wk of pre...

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Faecal calprotectin concentrations and diagnosis of necrotising enterocolitis

Cited by 104 publications

References 4 publications

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Effects of Bifidobacterium lactis Bb12 Supplementation on Body Weight, Fecal pH, Acetate, Lactate, Calprotectin, and IgA in Preterm Infants

Biochemical Investigations of Bowel Inflammation in Gastroschisis

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