Faecal elastase‐1 test is superior to faecal lipase test in the assessment of exocrine pancreatic function in cystic fibrosis

Walkowiak, Jarosław; Lisowska, Aleksandra; Przysławski, Juliusz; Grzymisławski, Marian; Krawczyński, Marian; Kh, Herzig

doi:10.1111/j.1651-2227.2004.tb02715.x

Cited by 43 publications

(40 citation statements)

References 12 publications

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“…Chymotrypsin can be used to monitor enzyme substitution therapy as it reflects the amount of enzymes taken by the patient (fecal excretion will be low in patients who are not compliant). However, diagnostic accuracy of fecal chymotrypsin and of fecal lipase appears to be inferior to that of fecal elastase [71,72]. …”

Section: Cystic Fibrosis and Other Hereditary Diseasesmentioning

confidence: 80%

Tests of pancreatic exocrine function – Clinical significance in pancreatic and non-pancreatic disorders

Keller

Aghdassi

Lerch

et al. 2009

Best Practice & Research Clinical Gastroenterology

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Section: Cystic Fibrosis and Other Hereditary Diseasesmentioning

confidence: 80%

Tests of pancreatic exocrine function – Clinical significance in pancreatic and non-pancreatic disorders

Keller

Aghdassi

Lerch

et al. 2009

Best Practice & Research Clinical Gastroenterology

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“…Fecal chymotrypsin is another indirect pancreatic function test, which has a lower sensitivity than E1 in CF patients [35]. Fecal lipase is not widely used, and it was shown that the diagnostic value of E1 is superior [36]. The classical Van de Kamer method of total stool fat content measurement is more cumbersome in application [15].…”

Section: Discussionmentioning

confidence: 99%

Secretin-enhanced Magnetic Resonance Cholangiopancreatography in Pancreatic Insufficient and Pancreatic Sufficient Cystic Fibrosis Patients

Jończyk‐Potoczna

Nowak

Mądry

et al. 2016

JGLD

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Background & Aims: Although indirect methods of assessment of the exocrine pancreatic function have become the standard of care in the monitoring of pancreatic status, it still remains a current clinical challenge. Our aim was to compare the width of the pancreatic duct in pancreatic insufficient (PI) and pancreatic sufficient (PS) cystic fibrosis (CF) patients using secretin-enhanced magnetic resonance cholangiopancreatography (SE-MRCP). Methods: Thirty-seven CF patients were enrolled for this cross-sectional study, including 21 PI and 16 PS, all of whom underwent SE-MRCP. Measurement of the diameter of the pancreatic duct was performed in the head, body, and the tail of the pancreas at the baseline and after 1, 2, 3, 5, and 10 minutes after secretin administration. Results: The diameter of the pancreatic duct in the head of the pancreas after 5 and 10 minutes of secretin injection was greater in PI than in PS patients (median = 2.0 mm [interquartile range: 1.6-3.0] vs. 2.0 mm [1.0-2.0] and 2.0 mm [1.4-2.0] vs 1.0 mm [1.0-2.0], p=0.047 and p=0.040, respectively). Areas under ROC curves for discriminating between PI and PS patients were 0.693 (95% CI 0.521-0.866) and 0.698 (95% CI 0.528-0.868), respectively. No other differences in the width of the duct were identified at the baseline or during SE-MRCP. Conclusions: The measurement of the diameter of the pancreatic duct during secretin stimulation does not allow for differentiating between PS and PI status in CF patients. Abbreviations: CF: cystic fibrosis; CFTR: cystic fibrosis transmembrane conductance regulator; ELISA: enzyme-linked immunosorbent assay; ERCP: endoscopic retrograde cholangiopancreatography; E1: elastase-1; MRI: magnetic resonance imaging; PI: pancreatic insufficient; PS: pancreatic sufficient; SCT gene: secretin gene; SE-MRCP: secretin-enhanced magnetic resonance cholangiopancreatography; T: tesla; TR: repetition time; TE: echo time.

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“…Se evaluaron el estado nutricional (valores estandarizados de talla y peso corporales, concentración de albúmina 23 ), la expresión clínica de la enfermedad (función pulmonar, espirometría, función pancreática exocrina, elastasa-1 fecal, [24][25][26] colonización por Pseudomonas aeruginosa y marcadores bioquímicos de daño hepático [ALT, AST, GGT, 27 TP 28 ]) al momento de la recolección de muestras de sangre en todos los pacientes. También se recabó información sobre diabetes y cirrosis hepática concurrentes.…”

Section: Población Y Métodosunclassified

Prevalencia de deficiencia de vitamina K y factores asociados en pacientes con fibrosis quística sin aporte suplementario

Krzyżanowska

Drzymała-Czyż

Rohovyk³

et al. 2018

Arch Argent Pediatr

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Faecal elastase‐1 test is superior to faecal lipase test in the assessment of exocrine pancreatic function in cystic fibrosis

Abstract: Among indirect tests, faecal elastase-1 test is superior to faecal lipase test in the assessment of exocrine pancreatic function in cystic fibrosis.

Cited by 43 publications

References 12 publications

Tests of pancreatic exocrine function – Clinical significance in pancreatic and non-pancreatic disorders

Tests of pancreatic exocrine function – Clinical significance in pancreatic and non-pancreatic disorders

Secretin-enhanced Magnetic Resonance Cholangiopancreatography in Pancreatic Insufficient and Pancreatic Sufficient Cystic Fibrosis Patients

Prevalencia de deficiencia de vitamina K y factores asociados en pacientes con fibrosis quística sin aporte suplementario

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