Faecal microRNA as a biomarker of the activity and prognosis of inflammatory bowel diseases

Ji, Yahong; Li, Xiaoli; Zhu, Ying; Li, Na; Zhang, Nana; Niu, Min

doi:10.1016/j.bbrc.2018.06.174

Cited by 51 publications

(36 citation statements)

References 25 publications

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“…The differentially expressed miRNAs in IBD include miR-199a, miR-1226, miR-548a, and miR-515-5p. They affected the growth of pathogen Fn and E. coli and the probiotic segmental filamentous bacteria (SFB), ultimately leading to the occurrence of IBD (Ji et al 2018 ). Besides, miRNAs can regulate the uptake of bacterial products to affect the intestinal pathology of the host (Dai et al 2015 ).…”

Section: The Gut Microbiota–mirna Interactions In Intestinal Homeostamentioning

confidence: 99%

The roles of the gut microbiota–miRNA interaction in the host pathophysiology

Chen

Wang

2020

Mol Med

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The gut microbiota regulates the biological processes of organisms acting like ‘another’ genome, affecting the health and disease of the host. MicroRNAs, as important physiological regulators, have been found to be involved in health and disease. Recently, the gut microbiota has been reported to affect host health by regulating host miRNAs. For example, Fusobacterium nucleatum could aggravate chemoresistance of colorectal cancer by decreasing the expression of miR-18a* and miR-4802. What’s more, miRNAs can shape the gut microbiota composition, ultimately affecting the host's physiology and disease. miR-515-5p and miR-1226-5p could promote the growth of Fusobacterium nucleatum (Fn) and Escherichia coli (E.coli), which have been reported to drive colorectal cancer. Here, we will review current findings of the interactions between the gut microbiota and microRNAs and discuss how the gut microbiota–microRNA interactions affect host pathophysiology including intestinal, neurological, cardiovascular, and immune health and diseases.

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Section: The Gut Microbiota–mirna Interactions In Intestinal Homeostamentioning

confidence: 99%

The roles of the gut microbiota–miRNA interaction in the host pathophysiology

Chen

Wang

2020

Mol Med

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“…In turn, dysregulated NF-κΒ pathway is one of the key elements for CD development and progression [ 99 ]. .Furthermore, multiple test correction rejected two upregulated miRNA (miR-1246 and miR-223), reported previously as associating with intestinal inflammation [ 37 , 100 ]. Of these, miR-1246 may be involved in NFAt proteins activation, which together with the activated NF-κΒ pathway may result in the expression of pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 81%

In search for interplay between stool microRNAs, microbiota and short chain fatty acids in Crohn’s disease - a preliminary study

et al. 2020

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Background Inflammatory bowel diseases are classic polygenic disorders, with genetic loads that reflect immunopathological processes in response to the intestinal microbiota. Herein we performed the multiomics analysis by combining the large scale surveys of gut bacterial community, stool microRNA (miRNA) and short chain fatty acid (SCFA) signatures to correlate their association with the activity of Crohn’s disease (CD). Methods DNA, miRNA, and metabolites were extracted from stool samples of 15 CD patients, eight with active disease and seven in remission, and nine healthy individuals. Microbial, miRNA and SCFA profiles were assessed using datasets from 16S rRNA sequencing, Nanostring miRNA and GC-MS targeted analysis, respectively. Results Pairwise comparisons showed that 9 and 23 taxa differed between controls and CD patients with active and inactive disease, respectively. Six taxa were common to both comparisons, whereas four taxa differed in CD patients. α-Diversity was lower in both CD groups than in controls. The levels of 13 miRNAs differed (p-value < 0.05; FC > 1.5) in CD patients and controls before FDR correction and 4 after. Of six SCFAs, the levels of two differed significantly (p-value < 0.05, FC > 1.5) in CD patients and controls, and the levels of four differed in patients with active and inactive CD. PLS-DA revealed models with smallest error rate for controls in bacterial component and inactive disease in metabolites. Conclusion A complex interrelationship may exist between gut dysbiosis, miRNA profiling and SCFA level in response to intestinal inflammation.

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“…Whether this is an indirect effect linked to the miR-146a-mediated induction of intestinal epithelial innate immune tolerance (79, 205) or due to a direct microbial activity of miR-146a has not been detangled yet. Ji et al demonstrated that human fecal miRNAs associated with inflammatory bowel disease have diverse effects on the proliferative activity of the intestinal bacteria F. nucleatum, E. coli and segmental filamentous bacteria following the uptake of these miRNAs by the microorganisms (206). Of note, data on the influence of fecal miRNAs on the developing intestinal microbiome in neonates and infants are missing to date.…”

Section: Microrna (Mirna)mentioning

confidence: 99%

Host Factors of Favorable Intestinal Microbial Colonization

Pirr

Viemann

2020

Front. Immunol.

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Gut microbial colonization starts with birth and initiates a complex process between the host and the microbiota. Successful co-development of both establishes a symbiotic mutual relationship and functional homeostasis, while alterations thereof predispose the individual lifelong to inflammatory and metabolic diseases. Multiple data have been provided how colonizing microbes induce a reprogramming and maturation of immunity by providing crucial instructing information to the newborn immune system. Less is known about what host factors have influence on the interplay between intestinal immunity and the composition of the gut microbial ecology. Here we review existing evidence regarding host factors that contribute to a favorable development of the gut microbiome and thereby successful maturation of gut mucosal immunity.

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Faecal microRNA as a biomarker of the activity and prognosis of inflammatory bowel diseases

Cited by 51 publications

References 25 publications

The roles of the gut microbiota–miRNA interaction in the host pathophysiology

The roles of the gut microbiota–miRNA interaction in the host pathophysiology

In search for interplay between stool microRNAs, microbiota and short chain fatty acids in Crohn’s disease - a preliminary study

Host Factors of Favorable Intestinal Microbial Colonization

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