Faecal Proteomics and Functional Analysis of Equine Melanocytic Neoplasm in Grey Horses

Tesena, Parichart; Kingkaw, Amornthep; Phaonakrop, Narumon; Roytrakul, Sittiruk; Limudomporn, Paviga; Vongsangnak, Wanwipa; Kovitvadhi, Attawit

doi:10.3390/vetsci9020094

Cited by 3 publications

(2 citation statements)

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“…Alongside the study of animal models for human diseases, as omics knowledge increased in human medicine, the multiomics approach began to be applied in the veterinary field with the aim of improving both animal and human health as well as animal husbandry productivity. As regards the “method” applicable in the study of omics profiles, the high-throughput technologies used in human medicine are the same as that suitable in veterinary medicine, as well as the different types of substrates that can be used, including plasma, serum, urine, feces, and saliva [31, 72, 73].…”

Section: Integrative Multiomics Approaches In Veterinary Medicinementioning

confidence: 99%

“…Major attention has been paid to veterinary oncology, not least because of the comparative insights with humans it provides. In particular, neoplastic diseases investigated through omics technologies are hematopoietic neoplasms [79][80][81][82], mammary tumors [83][84][85], oral neoplasms [86], neuroendocrine tumors [87], and melanocytic tumors [73,88]. Further disorders addressed by omics approaches include cardiopathies [89][90][91], endocrinopathies such as hyperadrenocorticism [92] and diabetes mellitus [93,94], hepatopathies [95][96][97], chronic kidney disease [98,99], and inflammatory/infectious diseases(i.e., sepsis [100], pyometra [101], and vector-borne diseases [102,103]).…”

Section: Integrative Multiomics Approaches In Veterinary Medicinementioning

confidence: 99%

See 1 more Smart Citation

Omics Technologies in Veterinary Medicine: Literature Review and Perspectives in Transfusion Medicine

Miglio,

Cremonini,

Leonardi

et al. 2023

Transfus Med Hemother

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Background: Omics technologies represent a new analytical approach that allows a full cellular readout through the simultaneous analysis of thousands of molecules. The application of such technologies represents a flourishing field of research in human medicine, especially in transfusion medicine, while their application in veterinary medicine still needs to be developed. Summary: Omics technologies, especially proteomics, metabolomics, and lipidomics, are currently applied in several fields of human medicine. In transfusion medicine, the creation and integration of multiomics datasets have uncovered intricate molecular pathways occurring within blood bags during storage. In particular, the research has been directed toward the study of storage lesions (SLs), i.e., those biochemical and structural changes that red blood cells (RBCs) undergo during hypothermic storage, their causes, and the development of new strategies to prevent them. However, due to their challenges to perform and high costs, these technologies are hardly accessible to veterinary research, where their application dates back only to the last few years and thus a great deal of progress still needs to be made. As regards veterinary medicine, there are only a few studies that have focused mainly on fields such as oncology, nutrition, cardiology, and nephrology. Other studies have suggested omics datasets that provide important insights for future comparative investigations between human and nonhuman species. Regarding the study of storage lesions and, more generally, the veterinary transfusion field, there is a marked lack of available omics data and results with relevance for clinical practice. Key Messages: The use of omics technologies in human medicine is well established and has led to promising results in blood transfusion and related practices knowledge. Transfusion practice is a burgeoning field in veterinary medicine, but, to date, there are no species-specific procedures and techniques for the collection and storage of blood units and those validated in the human species are univocally pursued. Multiomics analysis of the species-specific RBCs’ biological characteristics could provide promising results both from a comparative perspective, by increasing our understanding of species suitable to be used as animal models, and in a strictly veterinary view, by contributing to the development of animal-targeted procedures.

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Section: Integrative Multiomics Approaches In Veterinary Medicinementioning

confidence: 99%