Fagonia indica attenuates chromium-induced nephrotoxicity via antioxidant and anti-inflammatory activities in mice

Almilaibary, Abdullah; Elrefaei, Mohamed

doi:10.1016/j.heliyon.2022.e10373

Cited by 4 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One half was thoroughly dried with filter paper before being homogenized in PBS to yield a 10% homogenate. Supernatants were extracted to determine the levels of superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) [25]. The remaining half of each excised pancreas was fixed in paraffin and set in 10% paraformaldehyde.…”

Section: Methodsmentioning

confidence: 99%

Bee Honey Extract Attenuates Hyperglycemia in Induced Type 1 Diabetes: Impact of Antioxidant and Angiogenesis Activities on Diabetic Severity In Vivo

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background: Diabetes mellitus (DM) has become a disease prevalent worldwide. Honey, which comprises predominantly bioactive constituents, has anti-inflammatory, antioxidant, and immunomodulating properties. Aim: Recent developments and benefits of natural products in treating various diseases have caught the attention of researchers. This study aims to investigate the antidiabetic effect of bee honey extract on induced diabetic Swiss mice. Materials and Methods: Fifty Swiss male mice were randomly assigned to five groups of 10 mice each. Group I served as the negative control; in group II, the mice received 2 mg/kg/b.wt of honey extract only; and groups III, IV, and V received cyclosporine (CsA) (20 mg/kg/day, s.c.) daily for 10 days prior to receiving streptozotocin (STZ) inoculated at multiple low doses (MLDSTZ) (30 mg/kg/day, i.p.) for five consecutive days. Group IV was administered with insulin initiated at a dose of 0.5 U/kg/b.wt as a standard treatment (positive control). Group V was administered 2 mg/kg/b.wt of honey extract, while group III received no treatment. Results: The results showed a significant hypoglycemic effect, increased body weight, increased liver glycogen levels, and the amelioration of antioxidant activities in groups IV and V compared with the diabetic group III. Moreover, serum matrix metalloproteinase (MMP-9) concentrations were significantly reduced in the mice treated with the insulin and honey extract in groups IV and V and the tissue inhibitor metalloproteinase-1 (TIMP-1) levels were significantly higher than the serum levels in group III. Furthermore, the histopathological examination of groups IV and V revealed regenerative changes with the restoration of normal islet cell architecture, as compared to the diabetic mice in group III. Compared to group I, group II showed no changes and exhibited non-significant data. Conclusion: Honey extract plays an effective role in improving all biomarkers in treated group V. Furthermore, MMP-9 and TIMP-1 are considered prognostic markers in the progression, severity, diagnosis, and treatment of type 1 DM. This may play an important role for the treatment of individuals in the future.

show abstract

Section: Methodsmentioning

confidence: 99%

Bee Honey Extract Attenuates Hyperglycemia in Induced Type 1 Diabetes: Impact of Antioxidant and Angiogenesis Activities on Diabetic Severity In Vivo

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…This herb is used by the practitioners of Unani medicine as a blood purifier and to supplement cancer treatment ( Farheen et al, 2017 ). Numerous bioactive flavonoids, sterols, and triterpenoids are present in F. indica ( Almilaibary et al, 2022 ). Pharmacological testing has confirmed the plant's antibacterial ( Mustafa et al, 2016 ), anti-inflammatory ( Saleh et al, 2011 ), thrombolytic, antidiabetic ( Saleem et al, 2014 ), hepatoprotective ( Rasool et al, 2014 ), antioxidant, wound healing ( Rasool et al, 2014 ), and anticancer properties ( Waheed et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanistic insight into the synergistic antimicrobial potential of Fagonia indica Burm.f. extracts with cefixime

Abrar,

Zafar,

Fatima

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Renal Toxicology/Nephrotoxicity of Metals and Nanometallic Particles: Arsenic, Bismuth, Cadmium, Chromium, Indium, Lead, Platinum, Tungsten, Uranium, and Metallic Mixtures

Sanders,

Turkington

2024

Reference Module in Biomedical Sciences

View full text Add to dashboard Cite

Fagonia indica attenuates chromium-induced nephrotoxicity via antioxidant and anti-inflammatory activities in mice

Cited by 4 publications

References 41 publications

Bee Honey Extract Attenuates Hyperglycemia in Induced Type 1 Diabetes: Impact of Antioxidant and Angiogenesis Activities on Diabetic Severity In Vivo

Bee Honey Extract Attenuates Hyperglycemia in Induced Type 1 Diabetes: Impact of Antioxidant and Angiogenesis Activities on Diabetic Severity In Vivo

Mechanistic insight into the synergistic antimicrobial potential of Fagonia indica Burm.f. extracts with cefixime

Renal Toxicology/Nephrotoxicity of Metals and Nanometallic Particles: Arsenic, Bismuth, Cadmium, Chromium, Indium, Lead, Platinum, Tungsten, Uranium, and Metallic Mixtures

Contact Info

Product

Resources

About