Fagopyrum dibotrys extract alleviates hepatic steatosis and insulin resistance, and alters autophagy and gut microbiota diversity in mouse models of high-fat diet-induced non-alcoholic fatty liver disease

Zhang, Dan; Xu, Yingzi; Chen, Hang; Wang, Da; Geng, Zuotao; Chen, Yuanli; Chen, Yan; Xiong, Dayuan; Yang, Rongna; Liu, Xiaoting; Zhang, Yuke; Peng, Xiang; Ma, Lanqing; Li, Jianjun

doi:10.3389/fnut.2022.993501

Cited by 5 publications

(1 citation statement)

References 69 publications

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“…After mice were fed a high-fat diet, Bacteroidetes decreased dramatically and Firmicutes and Verrucomicrobium increased in the high-fat-diet group compared to the normal-diet group [55]. However, the intake of a high-fat diet in humans indicated the complete differences between mice and humans.…”

Section: Vitamin D3 Gut Microbiota and Gut Environmentmentioning

confidence: 94%

The Potential Use of Vitamin D3 and Phytochemicals for Their Anti-Ageing Effects

Santa,

Kumazawa,

Watanabe

et al. 2024

IJMS

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Unlike other vitamins, vitamin D3 is synthesised in skin cells in the body. Vitamin D3 has been known as a bone-related hormone. Recently, however, it has been considered as an immune vitamin. Vitamin D3 deficiency influences the onset of a variety of diseases. Vitamin D3 regulates the production of proinflammatory cytokines such as tumour necrosis factor-α (TNF-α) through binding to vitamin D receptors (VDRs) in immune cells. Since blood levels of vitamin D3 (25-OH-D3) were low in coronavirus disease 2019 (COVID-19) patients, there has been growing interest in the importance of vitamin D3 to maintaining a healthy condition. On the other hand, phytochemicals are compounds derived from plants with over 7000 varieties and have various biological activities. They mainly have health-promoting effects and are classified as terpenoids, carotenoids, flavonoids, etc. Flavonoids are known as the anti-inflammatory compounds that control TNF-α production. Chronic inflammation is induced by the continuous production of TNF-α and is the fundamental cause of diseases like obesity, dyslipidaemia, diabetes, heart and brain diseases, autoimmune diseases, Alzheimer’s disease, and cancer. In addition, the ageing process is induced by chronic inflammation. This review explains the cooperative effects of vitamin D3 and phytochemicals in the suppression of inflammatory responses, how it balances the natural immune response, and its link to anti-ageing effects. In addition, vitamin D3 and phytochemicals synergistically contribute to anti-ageing by working with ageing-related genes. Furthermore, prevention of ageing processes induced by the chronic inflammation requires the maintenance of healthy gut microbiota, which is related to daily dietary habits. In this regard, supplementation of vitamin D3 and phytochemicals plays an important role. Recently, the association of the prevention of the non-disease condition called “ME-BYO” with the maintenance of a healthy condition has been an attractive regimen, and the anti-ageing effect discussed here is important for a healthy and long life.

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Section: Vitamin D3 Gut Microbiota and Gut Environmentmentioning

confidence: 94%

The Potential Use of Vitamin D3 and Phytochemicals for Their Anti-Ageing Effects

Santa,

Kumazawa,

Watanabe

et al. 2024

IJMS

View full text Add to dashboard Cite

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Systematic analysis of the ARF gene family in Fagopyrum dibotrys and its potential roles in stress tolerance

Liu,

Ma,

Gao

et al. 2024

Genetica

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Fagopyrum dibotrys extract improves nonalcoholic fatty liver disease via inhibition of lipogenesis and endoplasmic reticulum stress in high-fat diet-fed mice

Wang,

Zhang,

Zhu

et al. 2024

BMC Res Notes

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Objective The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, presenting a treatment challenge due to limited options. Endoplasmic reticulum (ER) stress and associated lipid metabolism disorders are main causes of NAFLD, making it important to inhibit ER stress for effective treatment. Fagopyrum dibotrys has hypolipidemic, anti-inflammatory and hepatoprotective properties, showing promise in treating NAFLD. However, its effects on ER stress in NAFLD remain unclear. This study used a high-fat diet (HFD) to establish NAFLD mouse models and supplemented with Fagopyrum dibotrys extract (FDE) to evaluate its therapeutic effect and underlying mechanisms. Results We showed that FDE supplementation reduced the severity of hepatic steatosis and lowered triglycerides (TG) and total cholesterol (TC) levels in NAFLD mice. At the molecular level, FDE supplementation reduced hepatic lipid deposition by downregulating lipogenic markers (SREBP-1c, SCD1) and upregulating fatty acid oxidase CPT1α expression. Additionally, FDE treatment inhibited the overexpression of ER stress markers (GRP78, CHOP, and P-EIF2α) in NAFLD mice livers, and blocked the activation of the PERK-EIF2α-CHOP pathway, demonstrating its role in maintaining ER homeostasis. Considering that activation of the PERK pathway could exacerbate lipid deposition, our findings suggest that FDE has a protective effect against hepatic steatosis in NAFLD mice by attenuating ER stress, and the potential mechanism is through inhibiting the PERK pathway.

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Fagopyrum dibotrys extract alleviates hepatic steatosis and insulin resistance, and alters autophagy and gut microbiota diversity in mouse models of high-fat diet-induced non-alcoholic fatty liver disease

Cited by 5 publications

References 69 publications

The Potential Use of Vitamin D3 and Phytochemicals for Their Anti-Ageing Effects

The Potential Use of Vitamin D3 and Phytochemicals for Their Anti-Ageing Effects

Systematic analysis of the ARF gene family in Fagopyrum dibotrys and its potential roles in stress tolerance

Fagopyrum dibotrys extract improves nonalcoholic fatty liver disease via inhibition of lipogenesis and endoplasmic reticulum stress in high-fat diet-fed mice

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