2021
DOI: 10.1016/j.wneu.2020.10.170
|View full text |Cite
|
Sign up to set email alerts
|

Failed Hemispherotomy: Insights from Our Early Experience in 40 Patients

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
8
0
1

Year Published

2021
2021
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 13 publications
(9 citation statements)
references
References 16 publications
0
8
0
1
Order By: Relevance
“… 28 , 34 Epilepsy program and surgical experience has been shown to play a significant role in obtaining a complete anatomical disconnection and obtaining higher likelihood of seizure freedom and better outcome. 35 , 36 , 37 Although this variable was not explicitly studied in this analysis, the learning curve could potentially explain the higher seizure recurrence rate in lateral than in vertical hemispherotomies.…”
Section: Discussionmentioning
confidence: 99%
“… 28 , 34 Epilepsy program and surgical experience has been shown to play a significant role in obtaining a complete anatomical disconnection and obtaining higher likelihood of seizure freedom and better outcome. 35 , 36 , 37 Although this variable was not explicitly studied in this analysis, the learning curve could potentially explain the higher seizure recurrence rate in lateral than in vertical hemispherotomies.…”
Section: Discussionmentioning
confidence: 99%
“…It is unclear whether the neurosurgeon's experience should be measured by frequency of hemispheric surgeries, total number of hemispheric surgeries, or total number of years in practice. Kurwale et al performed a study that suggested 15–20 procedures are needed to achieve reasonable surgical skills in hemispherotomy 41 . A recent study found that increased years of surgeon experience was associated with a decreased likelihood of motor complications following peri‐Sylvian/insular epilepsy surgery 42 .…”
Section: Discussionmentioning
confidence: 99%
“…Kurwale et al performed a study that suggested 15-20 procedures are needed to achieve reasonable surgical skills in hemispherotomy. 41 A recent study found that increased years of surgeon experience was associated with a decreased likelihood of motor complications following peri-Sylvian/insular epilepsy surgery. 42 However, given the focus of the HOPS study, we did not explicitly collect data on surgeon experience and could not use the number of cases contributed by a center as a surrogate for surgeon experience.…”
Section: Discussionmentioning
confidence: 99%
“…Необходимо отметить, что многочисленные селективные ингибиторы PI3K и AKT находятся на стадии клинических испытаний для лечения пациентов со злокачественными опухолями различных локализаций, поэтому можно предположить их потенциальную эффективность при лечении эпилепсий, связанных с активацией пути PI3K/AKT/mTOR в спектре континуума МКР, поскольку нейропатологические фенотипы комплекса туберозного склероза, синдромов мутации PTEN и ГМЭ имеют много общего, включая дисламинацию коры, цитомегалию и дисморфию нейронов. На сегодня основным методом лечения ФРЭ при ГМЭ остается хирургическое вмешательствофункциональная гемисферотомия, которая купирует приступы у 65-85% пациентов в зависимости от патологического субстрата [5]. При этом когнитивные результаты обычно хуже, и в исследовании Global Pediatric Epilepsy Surgery Registry среди 45 детей после гемисферотомии около 43% имели среднее или слабое умственное развитие, 26% могли говорить соответственно возрасту, лишь 21% имел удовлетворительные навыки чтения.…”
Section: Discussionunclassified