Failed spinal anesthesia in addicts: Is it an incidence or coincidence?

Youssef, Mary; Abdelnaim, Hala Ezzat

doi:10.1016/j.egja.2014.02.001

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…We reported a series of cases with regular cannabis abuse who had repeated episodes of either failed or delayed effect of spinal anaesthesia. Multiple studies are already available favoring the interaction between cannabis abuse and anesthetic drugs used during general anaesthesia 5,6 . But, literature suggesting the effect of cannabis abuse over spinal anaesthesia is very sparse and limited.…”

Section: Discussionmentioning

confidence: 99%

“…Also, chronic use of cannabis and related compounds can influence many receptors centrally and peripherally in the nervous system including receptors involved in local anesthesia. The antinociceptive effect produced by cannabis is proposed to be mediated by a decreased calcium and increase potassium transmembrane conductance via inactivation of the voltage-activated channels 6,8 . Thus, leading to minimization of pain threshold along with escala-tion of the response towards pain stimuli as compare to non-abusers 7 .…”

Section: Discussionmentioning

confidence: 99%

“…All these compounds act on cannabinoid receptors, namely CB1 and CB2 which are present at different locations in the body 2,3,4 . Numerous studies suggested the interaction of cannabis and anesthetic drugs like propofol and thiopental affecting the pharmacodynamics in a patient with cannabis abuse under general anaesthesia 5,6 . But, the effect of cannabis abuse over spinal anaesthesia is not well understood till today, as very limited literature is available.…”

Section: Introductionmentioning

confidence: 99%

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Effect of cannabis abuse over spinal anaesthesia: A case series

Gupta¹,

Anant²,

Kumari³

et al. 2022

Serb J Anest Inten Therapy

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Introduction: In the modern world, drug abuse is one of the fastest emerging social issues. Cannabinoid receptor agonists are becoming increasingly popular as abused substance due to their ease of cultivation and availability. Case report: We present a series of three cases who were scheduled for lower limb surgeries planned under spinal anaesthesia. All patients were consuming either cannabis or its products regularly for significant time periods. All subjects were reported with an experience of either failed or delayed effect after the block. Conclusion: The study concluded that the incidence of failure of the spinal anaesthesia seemed to be higher in the cannabis abusers than among the non-abusers. There was a slower onset and decreased duration of both sensory and motor block in addict patients, with increase requirements of doses of anaesthetic and analgesic agents as compare to non-addict patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of cannabis abuse over spinal anaesthesia: A case series

Gupta¹,

Anant²,

Kumari³

et al. 2022

Serb J Anest Inten Therapy

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“…9 Repeat spinal anesthesia may have to be given in patients with kyphoscoliosis due to anatomical reasons preventing the spread of local anesthetic 10 and in addicts in whom tolerance to the drug may be the possible explanation as some of the narcotics have local anesthetic properties. 11 It thus forces the anesthetist for alternate interventions like repeat spinal or to proceed with general anesthesia which may be less favorable for the patient.…”

Section: Discussionmentioning

confidence: 99%

Failed Spinal Anesthesia; The Incidence in a Postgraduate Teaching Hospital

Ikram¹,

Samee²,

Amir³

et al. 2016

TPMJ

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To determine the frequency of failed spinal anesthesia in patients undergoing caesarean section in a teaching hospital in Pakistan. Study Design: It was a cross-sectional study. Setting: Department of Anesthesia and Pain Management PAF Hospital Sargodha. Period: January 2015 to May 2015. Methodology: A total of 293 pregnant patients undergoing caesarean section under spinal anesthesia were included. After prehydration and essential monitoring, all patients were given spinal anesthesia with 25 G spinal needle at L3-L4 or L4-L5 level by 2 nd year resident anesthesiologist under indirect supervision using 1.5 ml of hyperbaric spinal injection. Failure to achieve adequate block was managed by different modalities like sedation, analgesia with ketamine, repeat spinal anesthesia or to proceed with general anesthesia. Results: Out of total of 293 patients, failed spinal occurred in 9 patients (3.07%). Out of these 9 patients, 02 patients (22.22%) were elective caesarean sections while 07 cases (77.77%) were emergency caesarean sections. Conclusion: The chances of failed spinal anesthesia are more in emergency caesarean sections as compared to elective cases and failure rate of spinal anesthesia in PAF teaching hospital Sargodha is 3.07% which is slightly higher than 3%

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