Rollover crashes of buses are usually associated with multiple impacts that can result in complex interactions between passengers and a bus superstructure. Although there have been a few field data studies that provide some insights into occupant injuries (e.g. severity and distribution of injuries) during the real-world bus rollover crash, because they had used post-crash data, the occupant kinematics and injury mechanisms were not completely detailed in their results. Based on a literature review, available numerical and experimental studies on a bus rollover safety have mainly focused on structural integrity rather than considering occupant responses in their assessment. In addition, their results about occupant responses in bus rollover crashes show some discrepancies in terms of the estimated injury distribution, severity, and causes. Therefore, the main objective of this study was to provide a more detailed understanding of the occupant kinematics and associated injury risk during the ECE R66 tilt table bus rollover test using validated finite element (FE) models. The ECE R66 tilt table rollover was simulated using a full finite element model of the bus. A 50th percentile male Hybrid III Anthropomorphic test device (ATD) and EuroSID-2re FE models were selected to simulate the occupant’s motion. Each ATD was seated adjacent to the impacted side wall and restrained with a 2-point seatbelt. Simulation parameters included two impact surface friction values and different side window conditions. The results indicated that both ATD estimated the highest injury risk when the partial ejection occurred. They predicted a similar injury risk for the head and thorax. The ES-2re estimated a very low risk of neck injury in all simulations, whereas the Hybrid III estimated the high risk of a neck injury. Finally, recommendations to potentially reduce the injuries were provided and possible future works were suggested.