Failure of Benzoyl Peroxide to Decrease Sebaceous Gland Secretion in Acne

Goldstein, Jay A.; Pochi, Peter E.

doi:10.1159/000250285

Cited by 24 publications

(9 citation statements)

References 3 publications

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“…Discre pancies between the present data and previ ous reports [2,10,13,16] maybe explained by differences in BPO concentrations used and by differences in patient recruitment. But, other explanations may be considered as well.…”

Section: Discussioncontrasting

confidence: 61%

“…BPO was reported to produce a primary irritant dermatitis, and patients did not re port an improvement of seborrhea [1,2], In direct methods of assessing sebum pro duction were found to indicate a sebosuppressive effect of BPO [5,8], More estab lished methods for estimating SER also sug gested that BPO exerted a sebosuppressive effect [6] and clinical observations corrobo rated these observations [4], Other studies failed to show that BPO decreases sebaceous gland secretion in acne [10,13,16]. Recent- ly, 5% BPO was reported to increase SER by 22.5% in acne patients after 1 and 2 months of treatment [2].…”

Section: Discussionmentioning

confidence: 99%

“…But other studies did not corroborate the sebum-sup pressive effect of BPO [13,16]. Goldstein and Pochi [10] did not note any significant changes in SER in 10 male patients treated with 10% BPO gel for 6 weeks. Recently, Cunliffee tal.…”

Section: Introductionmentioning

confidence: 86%

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Sebum Suppression by Benzoylperoxide

et al. 1985

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Sebum excretion rate (SER) was determined by thin-layer chromatography and based on densitometric data in 9 male and 5 female patients suffering from acne during treatment with 10% benzoylperoxide (BPO). BPO was applied to the forehead (treatment area), whereas gel only was applied to the chest (control area) for 6 weeks. SER decreased in 10/14 subjects, no change was found in 1 subject and 3 patients exhibited an increase in SER. Suppression varied between 12 and 86%. Concomitant SER reduction in control and treatment areas was noted in 6 patients. When treatment and control areas of individual patients were considered for data evaluation, SER decrease was noted in only 4 out of 14 subjects. Similar results were obtained when free fatty acids, triglycerides and squalene data were analyzed. Combined, these data suggest that BPO may affect SER in some patients. The present experiments indicate the importance of adequate controls in such studies.

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

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Sebum Suppression by Benzoylperoxide

et al. 1985

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“…"''3 The site of increased airway resistance in patients with chronic limitation of airflow has been shown to be the small conducting airways,'4 where the obstruction appears to be due to an inflammatory process. [15][16][17][18][19][20] This study examines the nature of the condition in the central airways in patients with chronic bronchitis and determines its relation to the condition in the peripheral airways.…”

Section: Introductionmentioning

confidence: 99%

Acne: double blind clinical and laboratory trial of tetracycline, oestrogen-cyproterone acetate, and combined treatment.

Greenwood¹,

Brummitt²,

Burke³

et al. 1985

BMJ

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Since the recent introduction of a drug regimen containing 2 mg of the antiandrogen cyproterone acetate and 50 [ig ethinyloestradiol At six months the acne (as assessed by overali grade) had improved by 68% in the antibiotic treated group and by 74% in the oestrogen-cyproterone treated group. The group given a combination of both agents improved by 82%, which was significantly better (p<0025) than the improvement in the tetracycline treated patients. No significant difference was found between the groups given oestrogen-cyproterone alone and the combined treatment. The sebum excretion rate was suppressed by 25% in the patients in both groups receiving oestrogencyproterone but not in the group given antibiotics alone.Oestrogen-cyproterone acetate is as effective as antibiotics in treating acne in women, and adding antibiotics offers no advantage over using oestrogen-cyproterone on its own, although in this study the combination was more effective than tetracycline alone at six months.

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“…Benzoyl peroxide is considered by most authors as not having sebosuppressive action and some scientific works in fact show an increase in the sebumetric values in subjects treated with this active ingredient 10,17,18 . Other authors report that benzoyl peroxide has neither a positive nor a negative influence on sebaceous secretion whatsoever after topical treatment, attributing the discrepancy in results to the different measuring methods used on the cutaneous lipids and the different conditions when measuring 19 . Lastly, some authors found suppressive action on the sebaceous production 20 …”

Section: Discussionmentioning

confidence: 99%