Failure of gastric emptying and charcoal administration in fatal sustained-release theophylline overdose: Pharmacobezoar formation

Bernstein, George; Jehle, Dietrich; Bernaski, Edward; Braen, G. Richard

doi:10.1016/s0196-0644(05)81907-9

Cited by 44 publications

(17 citation statements)

References 11 publications

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“…The case of a cholestyramine pharmacobezoar occurred in a 10-month-old child with intestinal malrotation. Deaths resulted from bowel obstruction, sepsis, multi-organ failure, drug toxicity, and seizures (19,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Forensic Features of Pharmacobezoars

England

Heath

Gilbert

et al. 2014

Journal of Forensic Sciences

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Three cases of pharmacobezoars are reported to demonstrate typical autopsy findings and potential lethal mechanisms: (i) A 32-year-old woman died following an overdose of prescription medications. A gelatinous pharmacobezoar was found forming a cast of her bronchial tree. (ii) A 24-year-old woman also died following an overdose of prescription medications. At autopsy, two pharmacobezoars were present, one within the larynx and another occluding the right main bronchus. Deaths in both cases were attributed to airway occlusion by pharmacobezoars complicating mixed drug toxicity. (iii) A 79-year-old man was found dead in a car. Death was attributed to the combined effects of carbon monoxide and drug toxicity with a large pharmacobezoar lodged within the esophagus. Pharmacobezoars are specific types of bezoars that occur when pharmaceutical materials, such as tablets, suspensions, and/or drug delivery devices, aggregate and contribute to death by occluding airways with tenacious material or by eluting drugs.

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Section: Discussionmentioning

confidence: 99%

Forensic Features of Pharmacobezoars

England

Heath

Gilbert

et al. 2014

Journal of Forensic Sciences

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“…Há também aquelas de liberação contí-nua, com cápsula constituída de membrana semipermeável, que não alteram seu volume durante o processo digestivo (2,3,4) . Dentro desse contexto podemos observar os frequentes relatos de farmacobezoares compostos de verapamil (9,10) , nifedipina (3,6,11,12) e teofilina (4,13) de liberação lenta. Pacientes que ingerem diariamente um grande número de pílulas também estão sob maior risco (7,14) .…”

Section: Discussionunclassified

Doença de Crohn e farmacobezoar intestinal: relato de caso

Trece

Netto

Trece

et al. 2010

Rev bras. colo-proctol.

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“…The formation of pharmacobezoars is seen especially after massive acute overdoses or continuous ingestion of sustained‐release tablets or capsules. In those cases, an active substance may be released from the pharmacobezoar causing persistent or recurrent intoxication . Our literature search generated three descriptions of oesophageal pharmacobezoars: two relating to overdoses and one relating to the ingestion of an unknown ‘diet pill’.…”

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confidence: 99%

Oesophageal Obstruction from a Pharmacobezoar Resulting in Death

Mortensen

Munkholm

Dalhoff

et al. 2016

Basic Clin Pharma Tox

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Formation of an intestinal pharmacobezoar is a rare condition. It may form after intake of various oral pharmaceutical preparations of drugs, both as a result of an acute overdose and through chronic use of therapeutic doses of a drug. We report a case with a patient presenting with an oesophageal pharmacobezoar and complete obstruction of the oesophagus and severe toxic symptoms and death related to oral ingestion of multiple drugs.

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Failure of gastric emptying and charcoal administration in fatal sustained-release theophylline overdose: Pharmacobezoar formation

Cited by 44 publications

References 11 publications

Forensic Features of Pharmacobezoars

Forensic Features of Pharmacobezoars

Doença de Crohn e farmacobezoar intestinal: relato de caso

Oesophageal Obstruction from a Pharmacobezoar Resulting in Death

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