Failure of heparin to alter the outcome of pneumococcal meningitis.

Macfarlane, J T; Cleland, P G; Attai, E. D. E.; Greenwood, Brian

doi:10.1136/bmj.2.6101.1522

Cited by 16 publications

(9 citation statements)

References 3 publications

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“…The results of this study suggest that drugs that inhibit the formation of fibrin are possibly beneficial in patients with pneumococcal meningitis. One small study evaluated the use of heparin in patients with pneumococcal meningitis [24]. In this trial, 15 patients were randomly assigned to heparin or a control group; four out of seven patients (57%) in the heparin group died, compared with two out of eight patients (25%) in the control group (Fisher exact test, p = 0.64).…”

Section: Discussionmentioning

confidence: 99%

Diffuse Cerebral Intravascular Coagulation and Cerebral Infarction in Pneumococcal Meningitis

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Diffuse Cerebral Intravascular Coagulation and Cerebral Infarction in Pneumococcal Meningitis

et al. 2010

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“…8,10,11,18 However, we only found a few clinical studies analysing coagulation disorders in humans with bacterial meningitis. 13e15, 17,19 The epidemiology and staging of the disseminated intravascular coagulation (DIC) and its influence on the clinical course and outcome in bacterial meningitis seems not to be precisely defined. Additionally, there is a lack of widely accepted recommendations on adjunctive use of medications directly aimed at the coagulation system e presumably due to insufficient research in this field.…”

Section: Introductionmentioning

confidence: 99%

Coagulation, coma, and outcome in bacterial meningitis – An observational study of 38 adult cases

Kowalik

Smiatacz

Hlebowicz

et al. 2007

Journal of Infection

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“…Limited data suggest that anticoagulant therapy in patients with meningitis is associated with a higher rate of intracerebral hemorrhagic complications 15 and increased mortality. 16 With the exception of case reports, 17,18 there are no data on the use of heparin in patients with CVT and a concurrent infection. International guidelines for CVT also do not provide a separate recommendation on the use of heparin in this subgroup.…”

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confidence: 99%

Clinical Outcome of Anticoagulant Treatment in Head or Neck Infection–Associated Cerebral Venous Thrombosis

Zuurbier

Coutinho

Stam

et al. 2016

Stroke

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Background and Purpose-Local infections of the head or neck are a cause of cerebral venous thrombosis. Treatment of infectious cerebral venous thrombosis with heparin is controversial. We examined whether this treatment was associated with intracranial hemorrhagic complications and poor clinical outcome. Methods-We retrieved data from a prospective cohort study of 624 cerebral venous thrombosis patients. We compared patients with and without an infection of the head or neck and anticoagulated versus not anticoagulated. We examined death or dependency and new intracerebral hemorrhages. Results-Six hundred four of 624 patients were eligible for the study. Fifty-seven patients had an infection of the head or neck (9.4%). Comparing data between infection and noninfection patients, the frequency of therapeutic doses of heparin was similar in both groups (82.5% versus 83.7%). New intracerebral hemorrhages were more common in patients with an infection (12.3% versus 5.3%; P=0.04), but death or dependency did not differ between patients with and without an infection (15.8% versus 13.7%). In patients with an infection of the head or neck, there was no significant difference in the frequency of new intracerebral hemorrhages and poor outcome between patients who did or did not receive therapeutic doses of heparin. Conclusions-New intracerebral hemorrhages were more frequent in patients with an infection. The use of therapeutic doses of heparin did not seem to influence the risk of new intracranial hemorrhages or poor clinical outcome, but the number of patients who did not receive anticoagulation was too small to draw firm conclusions about safety of heparin in adults with cerebral venous thrombosis and an infection of the head or neck.

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Failure of heparin to alter the outcome of pneumococcal meningitis.

Cited by 16 publications

References 3 publications

Diffuse Cerebral Intravascular Coagulation and Cerebral Infarction in Pneumococcal Meningitis

Diffuse Cerebral Intravascular Coagulation and Cerebral Infarction in Pneumococcal Meningitis

Coagulation, coma, and outcome in bacterial meningitis – An observational study of 38 adult cases

Clinical Outcome of Anticoagulant Treatment in Head or Neck Infection–Associated Cerebral Venous Thrombosis

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