Failure of implantation in human in vitro fertilization and embryo transfer patients: The effects of altered progesterone/ estrogen ratios in humans and mice

Gidley-Baird, AA; O'Neill, C; Sinosich, MJ

doi:10.1016/0020-7292(87)90249-9

Cited by 39 publications

(51 citation statements)

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“…According to Gidley-Baird et al (1986) alterations in oestrogen and progesterone levels affect the reproductive outcome, but the P:E 2 ratio better predicts the implantation outcome than the absolute levels of either oestrogen or progesterone alone (Gidley-Baird et al, 1986;Ma et al, 2003). The present study is consistent with the work previously done by Gidley-Baird et al (1986) and Kramer et al (1990) in which they showed that a change in the P:E 2 ratio had detrimental effects on the number of implanting embryos in the mouse and rat respectively.…”

Section: The Effects Of Hyperstimulation On Progesterone and Oestrogesupporting

confidence: 83%

The effect of hyperstimulation on transforming growth factor β1 and β2 in the rat uterus: possible consequences for embryo implantation

Jovanović

Kramer

2010

Fertility and Sterility

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Section: The Effects Of Hyperstimulation On Progesterone and Oestrogesupporting

confidence: 83%

The effect of hyperstimulation on transforming growth factor β1 and β2 in the rat uterus: possible consequences for embryo implantation

Jovanović

Kramer

2010

Fertility and Sterility

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“…Implantation is the outcome of a synchronized communication of a hormonally prepared functional uterus and the blastocyst complex [10]. It has long been known that this communication is impaired in the IVF cycles using down-regulated controlled ovarian hyperstimulation (COH), and that it must definitely be replaced via the LPS treatment [1,3,[11][12][13][14]. Numerous mechanisms may have their roles in the deterioration of the luteal phase physiology in IVF treatment cycles, e.g.…”

Section: Discussionmentioning

confidence: 99%

Progesterone vaginal capsule versus vaginal gel for luteal support in normoresponder women undergoing long agonist IVF/ICSI cycles

Gün

Özdamar²,

Şahin³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to investigate the effects of two different vaginal progesterone forms, administered for luteal phase support, on pregnancy outcomes in normoresponder women aged < 35, who underwent long agonist IVF/ICSI-ET cycles. Material and methods:A retrospective cohort analysis was designed. Normoresponders with primary infertility, who underwent IVF/ICSI-ET cycles employing GnRH analogue and who received progesterone as either capsule or gel form for LPS following a single embryo transfer, were analyzed. The cycles were categorized into two groups: micronized progesterone vaginal capsule 600 mg/day (Group 1, n = 78) and progesterone vaginal gel 180 mg/day (Group 2, n = 99). Positive β-hCG, clinical pregnancy and ongoing pregnancy rates were analyzed.Results: Both, demographic and stimulation characteristics were comparable between the groups. No difference was observed between the capsule and the gel groups regarding positive β-hCG (33.3% and 28.3%, respectively; p = 0.580), clinical pregnancy (26.9% and 22.2%, respectively; p = 0.584), and ongoing pregnancy rates (21.8% and 20.2%, respectively; p = 0.942) after treatment completion. Conclusions:In long agonist IVF/ICSI-ET cycles, positive β-hCG, clinical pregnancy and ongoing pregnancy rates do not significantly differ between normoresponder patients receiving micronized progesterone vaginal capsule and those receiving progesterone vaginal gel for LPS.

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“…Plasma estradiol concentrations, however, were not affected by gonadotropin stimulation. In mice, the progesterone-to-estradiol ratio may be more critical to implantation rates than concentrations of each hormone (22,39), because estrogen and progesterone generally have antagonistic actions in the endometrium. Both rhFSH and eCG raised the plasma progesterone-to-estradiol ratio when compared with controls, but the increase was not significant after eCG.…”

Section: Discussionmentioning

confidence: 99%

Recombinant human follicle-stimulating hormone alters maternal ovarian hormone concentrations and the uterus and perturbs fetal development in mice

Kelley

Kind

Lane

et al. 2006

American Journal of Physiology-Endocrinology and Metabolism

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human follicle-stimulating hormone alters maternal ovarian hormone concentrations and the uterus and perturbs fetal development in mice. Am J Physiol Endocrinol Metab 291: E761-E770, 2006. First published May 23, 2006 doi:10.1152 doi:10. /ajpendo.00079.2006pins are routinely administered to produce multiple oocytes for clinical in vitro fertilization (IVF) treatment, laboratory research, and livestock industries. Studies in mice have shown gonadotropin stimulation using equine chorionic gonadotropin (eCG) affects the endometrium, implantation, and fetal development. Evidence from clinical studies also indicates that stimulation with recombinant human follicle-stimulating hormone (rhFSH) may be detrimental to the endometrium and implantation rates. We investigated the effect of rhFSH in mice on maternal plasma hormone concentrations and uterine gene and protein expression and the effect of a stimulated maternal environment on pregnancy. Adult females were stimulated with rhFSH or eCG, followed by human chorionic gonadotropin (hCG). On day 4 of pseudopregnancy, mice either had embryos transferred to the uterus or were killed, and blood and uterine samples were collected. Pregnancy outcomes were examined on day 15. Gonadotropin stimulation increased plasma progesterone concentrations on day 4 compared with controls, whereas estradiol concentrations were unaffected. Stimulation also reduced uterine leukemia inhibitory factor (Lif) mRNA, but the expression of estrogen and progesterone receptors (Esr1 and Pgr), homeobox gene Hoxa10, and Vegf mRNA were unchanged. Furthermore, distribution of uterine PGR protein expression was altered by stimulation, but LIF protein was unchanged. Stimulated embryo transfer recipients had lower pregnancy rates than controls, and fetuses from the rhFSH group had reduced weight, length, and maturity. These results demonstrate that gonadotropin stimulation with rhFSH or eCG alters the preimplantation maternal environment, which results in reduced pregnancy rates and fetal development in the mouse. endometrium; equine chorionic gonadotropin; ovarian stimulation; gonadotropin; mouse GONADOTROPIC HORMONES ARE routinely administered during in vitro fertilization (IVF) treatment to stimulate the ovaries to produce high numbers of oocytes. Typically, exogenous follicle-stimulating hormone (FSH) is used to mature multiple follicles, then human chorionic gonadotropin (hCG) mimics luteinizing hormone (LH) by inducing ovulation. Although this procedure is widely used in human IVF, laboratory research and livestock industries, the possible consequences of gonadotropin stimulation are largely unknown. Evidence from some studies indicates that stimulation before IVF causes endometrial abnormalities and may reduce implantation rates (6,13,33,34). Studies in mice have revealed that exogenous gonadotropins perturb embryo and oocyte development (15)(16)(17)(18)50) and cause changes to the mother (40, 44, 45), both of which contribute to reduced implantation rate, fetal development rate, and fetal weight (1...

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Failure of implantation in human in vitro fertilization and embryo transfer patients: The effects of altered progesterone/ estrogen ratios in humans and mice

Cited by 39 publications

References 0 publications

The effect of hyperstimulation on transforming growth factor β1 and β2 in the rat uterus: possible consequences for embryo implantation

The effect of hyperstimulation on transforming growth factor β1 and β2 in the rat uterus: possible consequences for embryo implantation

Progesterone vaginal capsule versus vaginal gel for luteal support in normoresponder women undergoing long agonist IVF/ICSI cycles

Recombinant human follicle-stimulating hormone alters maternal ovarian hormone concentrations and the uterus and perturbs fetal development in mice

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