Failure of inhibition of lipid peroxidation by vitamin E to protect against gentamicin nephrotoxicity in the rat

Ramsammy, Leslie S.; Josepovitz, Christine; Ling, Kit‐Yin; Lane, Bernard; Kaloyanides, George J.

doi:10.1016/0006-2952(87)90140-7

Cited by 51 publications

(24 citation statements)

References 23 publications

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“…[13] Some of previous experimental models have shown that vitamin E cannot prevent or even reduce the severity of gentamicin-induced proximal tubular cell necrosis (Ramsammy et al). [14] This was in corroboration in few dimensions of our study as well where vitamin E failed to control the dilating effect of Gentamicin in renal corpuscle and renal space.…”

Section: Resultssupporting

confidence: 87%

The Effect of Vitamin E in the Gentamicin Induced Nephrotoxicity in Wistar Albino Rats- A Histological Perspective

Yadav¹,

Awasthi²,

Pandey³

et al. 2017

IJTA

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Section: Resultssupporting

confidence: 87%

The Effect of Vitamin E in the Gentamicin Induced Nephrotoxicity in Wistar Albino Rats- A Histological Perspective

Yadav¹,

Awasthi²,

Pandey³

et al. 2017

IJTA

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“…As early as 1987, scientists were investigating the therapeutic action of vitamin E against AKI [18]. Ramsammy et al first investigated whether administering vitamin E could inhibit lipid peroxidation and prevent or ameliorate gentamicin-induced AKI in rats [18].…”

Section: Therapeutic Action Of Vitamin E Against Akimentioning

confidence: 99%

“…Ramsammy et al first investigated whether administering vitamin E could inhibit lipid peroxidation and prevent or ameliorate gentamicin-induced AKI in rats [18]. In their results, although the concurrent treatment of rats with vitamin E and gentamicin for six days did not produce an evident effect on the gentamicin-induced alterations of superoxide dismutase, malondialdehyde, catalase, or the glutathione cascade, the shift from polyunsaturated to saturated fatty acids was significantly reversed.…”

Section: Therapeutic Action Of Vitamin E Against Akimentioning

confidence: 99%

Protective effect of vitamin E against acute kidney injury

Liu

Feng

Wang

et al. 2015

BME

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Abstract. It has been well-known for many years now that vitamin E is an essential nutrient; however, some of the physiological functions of this vitamin are still far from being understood. In recent years, a series of preclinical and clinical studies proposed a protective role of vitamin E on acute kidney injury (AKI), which has a high morbidity rate and mortality rate in clinical investigations. Based on the benefits associated with vitamin E, such as strong antioxidant function, low toxicity, rare side-effects, and low cost, this therapy strategy has garnered an extensive amount of interest in the scientific community for the development of new therapy modes against AKI. In this review, a concise overview of the application of vitamin E in the treatment of AKI is provided as well as a summary of a series of published data regarding the combination therapy modes and detailed therapy mechanisms of vitamin E-based therapy against AKI. At present, there are critical points of this therapy mode that are still in need of further clarification, meaning the current understanding of the role of vitamin E in the treatment of AKI remains incomplete. However, the development of more reliable pharmacological or biotechnical strategies with vitamin E for the eventual treatment of patients with AKI may guide the next chapter of vitamin E research.

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“…santrifüj edildi. Santrifüj sonrası elde edilen süpernatantda SOD (15,12) İstatistik çalışmalara Student's t testi kullanıldı.…”

Section: Dokularin Anali̇ze Hazirlanişi Ve Akti̇vi̇te -Mi̇ktar Tayi̇nleri̇unclassified

“…Bu toksitenin mekanizması tam açıklanamamakla beraber bazı anti oksidanlann bu toksiteden koruyucu etki yapması bu hasarların radikal metabolizmasıyla ilişkili olabileceği düşüncesini akla getirmektedir (6,4,7,12,13,16).…”

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Kobaylarda Gentami̇si̇n'i̇n Karaci̇ğer Toksi̇tesi̇ni̇n Araştirilmasi : E Vi̇tami̇ni̇'ni̇n Etki̇si̇

Canbolat¹,

Kavutçu²,

Öztürk³

et al. 1995

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Failure of inhibition of lipid peroxidation by vitamin E to protect against gentamicin nephrotoxicity in the rat

Cited by 51 publications

References 23 publications

The Effect of Vitamin E in the Gentamicin Induced Nephrotoxicity in Wistar Albino Rats- A Histological Perspective

The Effect of Vitamin E in the Gentamicin Induced Nephrotoxicity in Wistar Albino Rats- A Histological Perspective

Protective effect of vitamin E against acute kidney injury

Kobaylarda Gentami̇si̇n'i̇n Karaci̇ğer Toksi̇tesi̇ni̇n Araştirilmasi : E Vi̇tami̇ni̇'ni̇n Etki̇si̇

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