Failure of Lymphocyte Transformation in Response to Gamma-Globulins in Rheumatoid Arthritis

Kacaki, J; Bullock, Ward E.; Vaughan, John H.

doi:10.1016/s0140-6736(69)92224-7

Cited by 20 publications

(17 citation statements)

References 8 publications

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“…The failure to stimulate peripheral blood lymphocytes from patients with rheumatoid arthritis using autologous aggregate-free, aggregated, or homologous IgG is in accord with a study recently reported by Kacaki et a2 (8) using commercial pooled human IgG. In contrast to these results, Dorner et al (7) have found that autologous IgG prepared by the gel filtration of serum would stimulate rheumatoid lymphocytes.…”

Section: Discussionsupporting

confidence: 83%

“…These studies have given conflicting results. Divergent findings have also been obtained in studies of the blood lymphocyte blast cell response in vitro to homologous and autologous IgG (7,8). In addition, Wilkinson et a1 (4) could not demonstrate a difference between patients with rheumatoid arthritis and controls using the Rebuck skin window technic to study the inflammatory response.…”

mentioning

confidence: 99%

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In vivo and in vitro responses to autologous IgG in patients with rheumatoid arthritis

Runge

Mills

1971

Arthritis & Rheumatism

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The presence of rheumatoid factor in patients with rheumatoid arthritis remains unexplained and may be etiologically important. An attempt has been made to determine whether patients with seropositive rheumatoid arthritis show basic immunologic responses to IgG. Various immunologic parameters of antigen recognition were measured in 9 patients and 3 controls. No immediate or delayed cutaneous hypersensitivity was noted to native or aggregated autologous IgG, nor could in vitro lymphocyte blast cell transformation be induced with these proteins. Rebuck skin windows showed no unusual responsiveness to native IgG. The negative results indicate that either IgG is not the immunogen responsible for rheumatoid factor or that patients with rheumatoid arthritis retain a state of partial tolerance. Evidence supporting the concept that rheumatoid factor may interfere with the phlogistic potential of aggregated γ‐globulin was also found.

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Section: Discussionsupporting

confidence: 83%

mentioning

confidence: 99%

In vivo and in vitro responses to autologous IgG in patients with rheumatoid arthritis

Runge

Mills

1971

Arthritis & Rheumatism

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“…Our results confirm the findings of other investigators (10,11) who demonstrated that lymphoid cells of blood from RA patients did not differ significantly from those of normal controls with respect to their in vitro responses to the various globulin preparations. Kinsella in a preliminary report (13) was able to demonstrate a higher response of RA blood lymphocytes to the aggregate HGG than that of normal blood lymphocytes.…”

Section: Introductionsupporting

confidence: 92%

“…DISCUSSION Previous attempts to demonstrate in vitro transformation of lymphocytes from rheumatoid patients upon incubation with the various globulin preparations have been unsuccessful (10,11). We felt that further study of this question was needed for several reasons.…”

Section: Introductionmentioning

confidence: 99%

“…(b) Fetal calf serum was used in some studies to support cell growth; such serum might contain nonspecific stimula- (3). In our experiments we attempted to avoid these possible artifacts by using one pool of globulin-free AB plasma in the culture medium; and by using more "physiologic" doses of antigen, 10 Ig, which would provide fewer molecules per cell receptor.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study of the In Vitro Proliferative Responses of Blood and Synovial Fluid Leukocytes of Rheumatoid Arthritis Patients

Reynolds¹,

Abdou²

1973

J. Clin. Invest.

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Cellular Immunity in Rheumatic Diseases I. Rheumatoid Arthritis

Waxman

Lockshin

Schnapp

et al. 1973

Arthritis & Rheumatism

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Cell-mediated immunity in rheumatoid arthritis (RA) was assessed by skin testing with 5 common antigens in 84 patients, dinitrochlorobenzene (DNCB) application in 13, and in Vitro phytohemagglutinin (PHA) stimulation of buffy coat cells in 39. Routine skin-test reactions were recorded as the largest diameter of induration present at 48 hours. Controls included normal subjects, family members of patients with rheumatic disorders, and patients with unrelated illnesses. Results revealed two populations of RA patients. Forty-two percent were completely anergic to the 5 antigens and 14% gave a history of herpes zoster. The remainder showed reactivity similar t o that seen in patient controls. Most RA subjects demonstrated normal or only minimally diminished PHA responses. The RA patients had normal inflammatory responses to the initial DNCB application, but immune reactions t o this agent paralleled skin-test reactivity t o the other antigens. The anergic individuals could be separated from the reactive population primarily by the increased duration of disease activity but not by medication taken or the degree of disease activity when tested.In rheumatoid arthritis (RA) the status of skin-test responsiveness and lymphocyte reactivity to phytohemagglutin (PHA) is in question. In some studies patients with kerato-

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Failure of Lymphocyte Transformation in Response to Gamma-Globulins in Rheumatoid Arthritis

Cited by 20 publications

References 8 publications

In vivo and in vitro responses to autologous IgG in patients with rheumatoid arthritis

In vivo and in vitro responses to autologous IgG in patients with rheumatoid arthritis

Comparative Study of the In Vitro Proliferative Responses of Blood and Synovial Fluid Leukocytes of Rheumatoid Arthritis Patients

Cellular Immunity in Rheumatic Diseases I. Rheumatoid Arthritis

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