Failure of Pituitary Response to Thyrotrophin-Releasing Hormone in Euthyroid Graves' Disease

Lawton, N. F.; Ekins, Roger; Nabarro, J. D. N.

doi:10.1016/s0140-6736(71)90006-7

Cited by 48 publications

(16 citation statements)

References 8 publications

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“…In 7 other patients (16%), normal TSH basal plasma level was found; however, TSH was hyporesponsive to TRH injection (i.e. euthyroid Graves' disease [10]. The 26 remaining patients had a normal TRH test (i.e.…”

Section: Resultsmentioning

confidence: 99%

Incidence and Significance of Organ-Specific Autoimmune Disorders (Clinical, Latent or only Autoantibodies) in Patients with Vitiligo

Betterle

Caretto

A³

et al. 1985

Dermatology

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The frequency of autoimmune disorders was determined in 373 vitiligo patients and in controls matched for sex, age and race. Vitiligo patients had an increased frequency of clinical autoimmune diseases of thyroid (7.5%), stomach (0.8%), parathyroid (1%), adrenal gland (1.3%). Vitiligo patients, without clinical signs of overt autoimmune diseases, also had a statistically significant increase in the frequency of gastric parietal cell (p < 0.001), thyroid microsomal (p < 0.05) and adrenal autoantibodies (p < 0.05). This increased incidence of autoimmune manifestations was correlated with the duration of vitiligo. Furthermore in 94% of the patients with parietal cell autoantibodies a gastric biopsy showed atrophic gastritis. In addition, in 48% of the patients with thyroid microsomal autoantibodies and in 2 out of 6 patients with adrenal autoantibodies without overt diseases at the beginning of the study, the functional investigation of the target organs during the follow-up allowed the detection of the presence or that of the subsequent development of clinical or subclinical dysfunction.

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Section: Resultsmentioning

confidence: 99%

Incidence and Significance of Organ-Specific Autoimmune Disorders (Clinical, Latent or only Autoantibodies) in Patients with Vitiligo

Betterle

Caretto

A³

et al. 1985

Dermatology

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“…The serum TSH response to intravenous thyrotrophin-releasing hormone (TRH) depends neither upon the presence of stimulating TSH receptor antibodies nor autonomous thyroid tissue, but upon the concentration of thyroid hormone in the circulation. A lack of response of serum TSH to TRH is invariable in thyrotoxicosis (Ormston et al, 1971) but may also occur in patients with exophthalmic Graves' disease (Lawton et al, 1971;Ormston et al, 1973) and in euthyroid patients with solitary autonomous thyroid nodules (Evered et al, 1974). The lack of response of serum TSH to TRH in these euthyroid patients is an indication of the sensitivity of the anterior pituitary gland to minor changes in the circulating levels of T3 and T4 within the normal range (Snyder & Utiger, 1972, 1973 and therefore the range of thyroid hormone levels for an individual within which a normal serum TSH response to TRH is obtained is much narrower than the normal range for the population.…”

Section: T3 Suppression Test and Trh Testmentioning

confidence: 99%

The Diagnosis and Treatment of Thyrotoxicosis

Irvine

Toft

1976

Clinical Endocrinology

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“…The availability of synthetic thyrotropin-releasing hormone (TRH)1 for clinical investigation has led to the Received for publication 13 (1,2), primary hypothyroidism (1,3,4), monotrophic TSH deficiency (5), and panhypopituitarism (3,4,6). Much (7,8).…”

Section: Introductionmentioning

confidence: 99%