Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men

Walker, Thomas B.; Altobelli, Stephen A.; Caprihan, Arvind; Robergs, Robert A.

doi:10.1016/j.metabol.2007.04.004

Cited by 32 publications

(39 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…None of the included studies are free of plausible bias (Figure 1), which raises potential concern about the validity of their results. In the domain of “other risk of bias”, six studies reporting non-significant results have a low risk of bias due to lack of sample size calculation [18,19,21,25,26], one calculated a sample size but did not specify a primary outcome [24] and three reported the use of outcome measurement tools that are not validated [19,24]. …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Rhodiola rosea for physical and mental fatigue: a systematic review

Ishaque

Shamseer

Bukutu

et al. 2012

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundRhodiola rosea (R. rosea) is grown at high altitudes and northern latitudes. Due to its purported adaptogenic properties, it has been studied for its performance-enhancing capabilities in healthy populations and its therapeutic properties in a number of clinical populations. To systematically review evidence of efficacy and safety of R. rosea for physical and mental fatigue.MethodsSix electronic databases were searched to identify randomized controlled trials (RCTs) and controlled clinical trials (CCTs), evaluating efficacy and safety of R. rosea for physical and mental fatigue. Two reviewers independently screened the identified literature, extracted data and assessed risk of bias for included studies.ResultsOf 206 articles identified in the search, 11 met inclusion criteria for this review. Ten were described as RCTs and one as a CCT. Two of six trials examining physical fatigue in healthy populations report R. rosea to be effective as did three of five RCTs evaluating R. rosea for mental fatigue. All of the included studies exhibit either a high risk of bias or have reporting flaws that hinder assessment of their true validity (unclear risk of bias).ConclusionResearch regarding R. rosea efficacy is contradictory. While some evidence suggests that the herb may be helpful for enhancing physical performance and alleviating mental fatigue, methodological flaws limit accurate assessment of efficacy. A rigorously-designed well reported RCT that minimizes bias is needed to determine true efficacy of R. rosea for fatigue.

show abstract

Section: Resultsmentioning

confidence: 99%

“…A double-blind cross-over RCT examined the effect of R. rosea on exercise performance in twelve male subjects [25]. Subjects received R. rosea or identical placebo for 3 days before outcomes were measured by an exercise test and another dose on the day of the test.…”

Section: Resultsmentioning

confidence: 99%

Rhodiola rosea for physical and mental fatigue: a systematic review

Ishaque

Shamseer

Bukutu

et al. 2012

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…The selection of the R. rosea dose was based upon prior studies of healthy volunteers treated for short durations (Shevtsov et al, 2003; Walker et al, 2007) and one prior antidepressant trial (Darbinyan et al, 2007). The paucity of pharmacokinetic and pharmacodynamic profiles of R. rosea (or its constituents), made it difficult to determine the optimal dosing strategy.…”

Section: Discussionmentioning

confidence: 99%

Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial

et al. 2015

View full text Add to dashboard Cite

Background We performed a proof of concept trial to evaluate relative safety and efficacy of Rhodiola rosea (R. rosea) versus sertraline for mild to moderate major depressive disorder. Hypothesis We hypothesize that R. rosea would have similar therapeutic effects as sertraline but with less adverse events. Study Design Phase II randomized placebo controlled clinical trial Methods 57 subjects were randomized to 12 weeks of standardized R. rosea extract, sertraline, or placebo. Changes over time in Hamilton Depression Rating (HAM-D), Beck Depression Inventory (BDI), and Clinical Global Impression Change (CGI/C) scores among groups were examined using mixed-effects models. Results Modest, albeit statistically non-significant, reductions were observed for HAM-D, BDI, and CGI/C scores for all treatment conditions with no significant difference between groups (p=0.79, p=0.28, and p=0.17, respectively). The decline in HAM-D scores was greater for sertraline (−8.2, 95% confidence interval [CI], −12.7 to −3.6) versus R. rosea (−5.1, 95% CI: −8.8 to −1.3) and placebo (−4.6, 95% CI: −8.6 to −0.6). While the odds of improving (versus placebo) were greater for sertraline (1.90 [0.44–8.20]; odds ratio [95% CI]) than R. rosea (1.39 [0.38–5.04]), more subjects on sertraline reported adverse events (63.2%) than R. rosea (30.0%) or placebo (16.7%) (p=0.012). Conclusions Although R. rosea produced less antidepressant effect versus sertraline, it also resulted in significantly fewer adverse events and was better tolerated. These findings suggest that R. rosea, although less effective than sertraline, may possess a more favorable risk to benefit ratio for individuals with mild to moderate depression.

show abstract

“…Abidov, Grachev, Seifulla, and Zigenfuss (2004) found that supplementation with R. rosea significantly decreased changes in inflammatory parameters (C-reactive protein) and skeletal-muscle damage markers (creatine kinase) induced by intensive physical exercise. However, these favorable effects have not been confirmed in humans (Colson et al, 2005;Walker, Altobelli, Caprihan, & Robergs, 2007).…”

mentioning

confidence: 93%

The Influence of Supplementation with Rhodiola rosea L. Extract on Selected Redox Parameters in Professional Rowers

Skarpańska-Stejnborn¹,

Basta²,

Deskur-Śmielecka³

2009

International Journal of Sport Nutrition and Exercise Metabolism

View full text Add to dashboard Cite

The aim of this study was to investigate the effect of Rhodiola rosea supplementation on the balance of oxidants and antioxidants in the serum and erythrocytes of competitive rowers. This double-blinded study included 22 members of the Polish Rowing Team who were participating in a preparatory camp. Participants were randomly assigned to the supplemented group (n = 11), who received 100 mg of R. rosea extract twice daily for 4 wk, or the placebo group (n = 11). At the beginning and end of the study, participants performed a 2,000-m maximum test on a rowing ergometer. Blood samples were taken from the antecubital vein before each exercise test, 1 min after completing the test, and after a 24-hr restitution period. The following redox parameters were assessed in erythrocytes: superoxide dismutase activity, glutathione peroxidase activity, and thiobarbituric-acid-reactive substances concentrations. In addition, creatine kinase activity and total antioxidant capacity were measured in plasma samples, lactate levels were determined in capillary blood samples, and uric acid concentrations were measured in serum. After supplementation, the total plasma antioxidant capacity was significantly higher (p = .0002) in the supplemented group than in the placebo group, and superoxide dismutase activity in erythrocytes directly after and 24 hr after the ergometry was significantly (p = .0461) lower in athletes receiving R. rosea extracts than in the placebo group. In conclusion, supplementation with R. rosea increased antioxidant levels in the plasma of professional rowers but had no effect on oxidative damage induced by exhaustive exercise.

show abstract

Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men

Cited by 32 publications

References 21 publications

Rhodiola rosea for physical and mental fatigue: a systematic review

Rhodiola rosea for physical and mental fatigue: a systematic review

Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial

The Influence of Supplementation with Rhodiola rosea L. Extract on Selected Redox Parameters in Professional Rowers

Contact Info

Product

Resources

About