Failure of Setting of Mineral Trioxide Aggregate in the Presence of Fetal Bovine Serum and Its Prevention

Kim, Yuran; Kim, Sinyoung; Shin, Yoo Seok; Jung, Ioan; Lee, Seung Jong

doi:10.1016/j.joen.2011.12.005

Cited by 39 publications

(28 citation statements)

References 26 publications

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“…Similar effects have been reported when foetal bovine serum was used to contaminate the surface of MTA [ 30 ]. The hydration state of MTA mixed with blood has also been reported [ 39 ] with specimens partially mixed with blood being more completely hydrated than those mixed entirely with blood and less than specimens hydrated completely with water.…”

Section: Physical Propertiessupporting

confidence: 63%

“…The surface of the MTA/ water was biphasic, containing large hexagonal crystalline plates composed of calcium embedded in a pool of globular crystals [ 60 ]. In addition, a recent study investigating the setting of MTA Angelus and ProRoot MTA in the presence of foetal bovine serum demonstrated a lack of hydration in contact with the solution [ 30 ]. The micro-hardness of MTA was adversely affected when the material was placed in contact with foetal bovine serum [ 27 ].…”

Section: Chemical Reagentsmentioning

confidence: 99%

See 1 more Smart Citation

Reactivity and Environmental Factors

Camilleri

Dummer

2014

Mineral Trioxide Aggregate in Dentistry

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Hydrated mineral trioxide aggregate (MTA) is composed of un-hydrated cement particles, which acts as a core around which a reaction rim of hydration products is formed ( Fig. 2.5 ). When mixed with water, the tricalcium and dicalcium silicate react forming calcium silicate hydrate (honeycomb appearance) and calcium hydroxide (hexagonal plates) (Fig. 2.6 ), which is leached in solution. The presence of calcium hydroxide has been verifi ed by X-ray diffraction analysis as it produces a typical peak for portlandite at 18° 2 θ (Fig. 2.9 ), whilst the leaching of calcium has been measured by inductively coupled plasma. The particular microstructure of MTA and the presence of calcium hydroxide in solution make the material susceptible to environmental factors. The use of MTA brings it into contact with other materials, tissues and fl uids, and a number of changes occur within or on the surface of the material in various environmental conditions. Effect of Environmental Factors on the Set MaterialMTA has a variety of applications mostly in Endodontics. These various uses have been discussed [ 60 ] and are outlined in Chap. 6 . Dental Materials Glass IonomerCovering MTA with glass ionomer cement when it is used as a pulp capping agent results in physical changes to the materials at their interface ( Fig. 5.1a ). A sizable gap has been observed at the interface attributed to the movement of water out of MTA into the glass ionomer. This movement of water out of MTA can inhibit its hydration and increases its porosity [ 9 ]. There is no evidence that covering MTA with a glass ionomer has an effect on the glass ionomer cement itself with regard to setting time and setting reaction [ 5 , 36 ]. However, migration of strontium from glass ionomer to MTA has been observed [ 9 ], although its effects are unknown. Base MaterialsZinc oxide eugenol-based cements are used as temporary fi lling materials and come into contact with MTA when it is used for pulp capping. Zinc is a retarder of cement hydration [ 47 ], and zinc salts form calcium hydrozincate (Ca(Zn(OH) 3 H 2 O) 2 ), an insoluble hydroxide in alkaline solution that creates a coating on MTA particles. In addition, zinc

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Section: Physical Propertiessupporting

confidence: 63%

Section: Chemical Reagentsmentioning

confidence: 99%

Reactivity and Environmental Factors

Camilleri

Dummer

2014

Mineral Trioxide Aggregate in Dentistry

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show abstract

“…Furthermore, Kim et al (22) reported that MTA failed to set in the presence of FBS. There also have been reports that the washout of MTA can occur when MTA is used as a retrograde filling material (13,14,22). Initial looseness of MTA, ie, it is not set or weakened physical condition, occurs in the presence of tissue fluid or blood flow and may threaten the hermetic sealing of communicating channels between the root canal system and the periradicular tissues, thereby resulting in the failure of endodontic surgery.…”

Section: Discussionmentioning

confidence: 99%

“…After endodontic surgery, the retrograde-filled MTA that is not set may encounter blood or tissue fluid. Kim et al (13) reported that washout of MTA could be mediated by continuous exudates or tissue fluid. Although MTA has excellent sealing ability, its washout can prevent the complete sealing of the retrograde preparation site of the tooth and thus eventually cause failure (13,14).…”

mentioning

confidence: 99%

Biological Effects and Washout Resistance of a Newly Developed Fast-setting Pozzolan Cement

Choi

Park

Lee

et al. 2013

Journal of Endodontics

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“…The setting of MTA and tricalcium silicate cement-based materials is impaired in the presence of synthetic tissue fluids (24)(25)(26). Synthetic tissue fluids contain phosphate ions and glucose, both of which are implicated in the retardation of setting of tricalcium silicate-based materials.…”

Section: Basic Research-technologymentioning

confidence: 99%