Failure of treatment in chronic dermatophyte infections

Hay, Roderick J.

doi:10.1136/pgmj.55.647.608

Cited by 29 publications

(16 citation statements)

References 14 publications

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“…It is not clear if chronic dermatophytosis stimulates IgE production or if this condition tends to develop in persons who are already atopic (127). A frequent pattern seen in these patients is the presence of immediate, but not delayed, hypersensitivity to trichophytin (110,112,122,134). However, many patients with chronic dermatophytosis neither are atopic nor manifest immediate hypersensitivity to trichophytin, indicating that other factors must also be involved in producing susceptibility to this type of infection.…”

Section: Dermatophytosismentioning

confidence: 99%

Cutaneous defenses against dermatophytes and yeasts

1995

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Predispositions to the superficial mycoses include warmth and moisture, natural or iatrogenic immunosuppression, and perhaps some degree of inherited susceptibility. Some of these infections elicit a greater inflammatory response than others, and the noninflammatory ones are generally more chronic. The immune system is involved in the defense against these infections, and cell-mediated immunity appears to be particularly important. The mechanisms involved in generating immunologic reactions in the skin are complex, with epidermal Langerhans cells, other dendritic cells, lymphocytes, microvascular endothelial cells, and the keratinocytes themselves all participating in one way or another. A variety of defects in the immunologic response to the superficial mycoses have been described. In some cases the defect may be preexistent, whereas in others the infection itself may interfere with protective cell-mediated immune responses against the organisms. A number of different mechanisms may underlie these immunologic defects and lead to the development of chronic superficial fungal infection in individual patients. Although the immunologic defects appear to be involved in the chronicity of certain types of cutaneous fungal infections, treatment of these defects remains experimental at the present time.

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Section: Dermatophytosismentioning

confidence: 99%

Cutaneous defenses against dermatophytes and yeasts

1995

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“…The prevalence of Trichophyton-induced superficial skin mycosis is very high among human diseases [1,2]. It is treated with antifungal agents, but recurs frequently and reduction of the number of patients has not been achieved.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Trichophyton antigen-induced contact hypersensitivity in mouse

Nakamura

Nishibu

Yasoshima³

et al. 2012

Journal of Dermatological Science

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“…Chronic dermatophyte infections pose similar problems in treatment. It is hoped that newer antifungal compounds or immunologically active drugs may help to improve the cure rate, particularly in 'dry' dermatophytosis caused by T. rubrum (Hay, 1979).…”

Section: Resultsmentioning

confidence: 99%

Treatment of superficial fungal infections*

Hay

1981

Clin Exp Dermatol

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Failure of treatment in chronic dermatophyte infections

Cited by 29 publications

References 14 publications

Cutaneous defenses against dermatophytes and yeasts

Cutaneous defenses against dermatophytes and yeasts

Analysis of Trichophyton antigen-induced contact hypersensitivity in mouse

Treatment of superficial fungal infections*

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