Failure to detect linkage between Xg and other X‐borne loci in Sardinians

X-mapping in man: evidence against measurable linkage between anhidrotic ectodermal dysplasia and G6PD deficiency.

“…10), the ratio for this linkage comparison becomes 2nr :4r. The data bearing on the latter linkage comparison are in agreement with the absence of measurable linkage between the relevant loci established by previous studies (Siniscalco et al, 1966). The six nonrecombinants between AED and Xg, when added to the ratio reported so far of 3nr:9r do not change the conclusion of an absence of measurable linkage between these loci (Race and Sanger, 1975).…”

Additional pedigree supporting the frequent origin of XXYY from consecutive meiotic non-disjunction in paternal gametogenesis.

“…In the course of a population study on Klinefelter's syndrome in the island of Sardinia, where the incidence of G6PD deficiency of Mediterranean type may be as high as 30% among males (Siniscalco et al, 1966), we found an XXYY male born to a G6PD-deficient father and to a mother who is an obligatory heterozygote for the Gd Mediterranean mutant.…”

“…In the course of a population study on Klinefelter's syndrome in the island of Sardinia, where the incidence of G6PD deficiency of Mediterranean type may be as high as 30% among males (Siniscalco et al, 1966) (Rinaldi et al, 1976). This conclusion is supported by the analysis of the red cell G6PD phenotypes of all members of the pedigree (Fig.…”

Human Genetics

“…This became of special interest when de tectable linkage was reported for the Xg locus and the glucose-6-phosphate dehydrogenase (Cd) locus (4, 101). Failure to verify this linkage in Sardi nians (282 ) led to extension of the studies in Israel and the conclusion that the available evidence does not favor linkage (3).…”