Failure to induce bladder cancer in mice:Bladder implantation with paraffin wax pellets of lypholized urine from bilharzial patients

El-Ghaffar, Yasin Abd

doi:10.1002/1097-0142(196609)19:9<1225::aid-cncr2820190908>3.0.co;2-k

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Infection with S. hematobium resulted in epithelial proliferation, squamous cell metaplasia and transitional cell carcinoma of the urinary bladder in a talapoin monkey (Cercopithecus talapoin), a capuchin monkey (Cebus apella), gibbons (Hybbates lar), and opossums (Didelphy marsupialis) [35][36][37][38]. S. hematobium ova, lyophilized worms and urine from schistosomal patients were not found to be carcinogenic to mice [39,40].…”

Section: Experimental Evidencementioning

confidence: 99%

Schistosomiasis and Neoplasia

Yosry

2006

Infection and Inflammation: Impacts on Oncogenesis

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Schistosomiasis is endemic in at least 75 tropical and subtropical countries where 600 million people are at risk of which over 200 million are infected. Three species, S. hematobium, S. mansoni and S. japonicum, account for the majority of human infections. There is sufficient evidence that S. hematobium, the predominant etiologic agent for urinary schistosomiasis, is carcinogenic to humans leading to squamous cell carcinoma of the urinary bladder, a relatively uncommon vesical cancer in nonendemic areas. There is limited evidence suggesting that S. japonicum is possibly carcinogenic to humans leading to colorectal cancer and is a risk factor for hepatocellular carcinoma formation. There is inadequate evidence for the carcinogenicity of S. mansoni in humans. S. mansoni may still be linked to hepatocellular carcinoma through potentiating the effects of hepatitis B virus and hepatitis C virus on the liver. In this article, the relationship between schistosomiasis and neoplasia will be reviewed.

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Section: Experimental Evidencementioning

confidence: 99%

Schistosomiasis and Neoplasia

Yosry

2006

Infection and Inflammation: Impacts on Oncogenesis

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Parasites

Azzouni

Diab

2017

Holland‐Frei Cancer Medicine

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Overview Many parasites were studied for a possible role in oncogenesis. Schistosoma haematobium was proved to play an important role in developing urinary bladder cancer. Other Schistosoma species, Schistosoma japonicum is classified as a colorectal carcinogen especially in the Far East. Other helminths Clonorchis and Opisthorchis are proved to induce hepatobiliary cancer. In Africa, a strong correlation between Ebstein–Barr virus infection and Burkitt lymphoma is present, with an evident enhancing role for Plasmodium falciparum . Chronic inflammation was incriminated to be the most accepted mechanism for parasite‐induced cancer; however, the roles of certain carcinogens, oncogenes, DNA mutations, and others were all approved as mechanisms enhancing carcinogenesis in parasitic infections. Strikingly, despite the above‐mentioned data, it seemed that certain parasites can modulate the host immune response in a manner that could lead to cancer regression or prevention. This is in the prospect of revaluation of the clinical importance of infectious agents; an issue that requires future concern.

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Parasites

Azzouni¹,

Matar²,

Galal³

et al. 2022

Holland‐Frei Cancer Medicine

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Overview Several parasites were investigated for a possible role in oncogenesis. Among the well‐known parasitic infections, Schistosoma haematobium was proved to play an important role in developing urinary bladder cancer. Moreover, Schistosoma japonicum is classified as a colorectal carcinogen especially in the Far East. Other class of parasites, such as helminths Clonorchis and Opisthorchis are proved to induce hepatobiliary cancer. In Africa, a strong correlation between Ebstein‐Barr virus infection and Burkitt lymphoma is present, with an evident enhancing role for Plasmodium falciparum . Chronic inflammation was incriminated to be the most accepted mechanism for parasite‐induced cancer; however, the roles of certain carcinogens, oncogenes, DNA mutations, and others were all approved as mechanisms enhancing carcinogenesis in parasitic infections. Strikingly, despite the above‐mentioned data, it seemed that certain parasites could modulate the host immune response in a manner that would lead to cancer regression or prevention. This is in the prospect of revaluation of the clinical importance of infectious agents; an issue that requires future concern.

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Failure to induce bladder cancer in mice:Bladder implantation with paraffin wax pellets of lypholized urine from bilharzial patients

Cited by 3 publications

References 6 publications

Schistosomiasis and Neoplasia

Schistosomiasis and Neoplasia

Parasites

Parasites

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