Failure to repair the c.338C&gt;T mutation in carnitine palmitoyl transferase 2 deficient skin fibroblasts using chimeraplasty

In the European Union, the definition of a GMO is technology-based. This means that a novel organism will be regulated under the GMO regulatory framework only if it has been developed with the use of defined techniques. This approach is now challenged with the emergence of new techniques. In this paper, we describe regulatory and safety issues associated with the use of oligonucleotide-mediated mutagenesis to develop novel organisms. We present scientific arguments for not having organisms developed through this technique fall within the scope of the EU regulation on GMOs. We conclude that any political decision on this issue should be taken on the basis of a broad reflection at EU level, while avoiding discrepancies at international level.

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Commentary: Genetic modification through oligonucleotide-mediated mutagenesis. A GMO regulatory challenge?

Breyer

Herman

Brandenburger

et al. 2009

Environ. Biosafety Res.

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Failure to repair the c.338C>T mutation in carnitine palmitoyl transferase 2 deficient skin fibroblasts using chimeraplasty

Cited by 1 publication

References 22 publications

Commentary: Genetic modification through oligonucleotide-mediated mutagenesis. A GMO regulatory challenge?

Commentary: Genetic modification through oligonucleotide-mediated mutagenesis. A GMO regulatory challenge?

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