We have evaluated four current Food and Drug Administration-cleared rapid tests for human immunodeficiency virus (HIV)-specific antibodies with a panel of specimens from recently infected individuals. Recent infection was detected by RNA-based screening coupled with enzyme immunoassay-based testing. We found that the sensitivities of the various rapid tests vary greatly with regard to their ability to detect HIV-specific antibodies in recently infected individuals.The persistence of the human immunodeficiency virus (HIV) pandemic is in part the result of the inability to comprehensively test all at-risk individuals. Even when at-risk individuals submit to laboratory testing, the inherent limitations of laboratory-based testing can lead to the failure to identify or inform infected individuals. Such limitations include the window periods associated with antibody-based testing (the time between infection and the generation of detectable antibodies in the blood) and the limited sensitivities of certain antibody tests (2,3,11,22). Moreover, the turnaround time associated with the logistics of laboratory-based testing can result in patients not obtaining their test results (6,7,9,17,20). Point-ofcare testing (rapid testing) for HIV infection seeks to broaden the capacity of the public health and medical communities to identify and to inform infected individuals. Rapid tests are easy to perform and can give conclusive results within minutes, making them amenable for use in outreach centers, emergency rooms, doctor's offices, and clinics.