Failures of the Oxygen Supply

Botney, Richard; Answine, Joseph F.; Cowles, Charles E.

doi:10.1016/j.anclin.2020.08.005

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…An OSF simulation scenario and evaluation checklists were created based on a previous review of management of OSF during general anesthesia[ 8 ] before initiation of data collection by two research investigators (FW, KN). In the simulation scenario, a study participant was expected to identify sudden OSF immediately after an earthquake that occurred during general anesthesia in the operating room and manage the situation by maintaining the oxygen supply to the patient.…”

Section: Methodsmentioning

confidence: 99%

“…Two research investigators (FW and KN) developed the evaluation checklists that evaluated whether the participants performed the predetermined key actions in the simulated OSF scenario. The evaluation checklists were developed by referring to previous literature,[ 8 ] and the final version of the checklists were verified through the agreement of two research investigators who had board certifications in anesthesiology from Japan (FW, KN). In the checklists, the participants were scored one point for the successful performance of each key action in Steps 1 and 2 [ Table 1 ].…”

Section: Methodsmentioning

confidence: 99%

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Efficacy of in-situ simulation training using evaluation checklists for sudden oxygen supply failure during general anesthesia

Kojima

Nishida²,

Watanabe³

2023

Saudi Journal of Anaesthesia

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Introduction: Sudden oxygen supply failure (OSF) is a life-threatening consequence that may be triggered by natural disasters. Anesthesiologists are required to manage OSF promptly in such catastrophic situations. However, the current evidence regarding the efficacy of anesthesia training for sudden OSF is insufficient. This preliminary study aimed to introduce our in-situ simulation training utilizing evaluation checklists for a sudden OSF situation during general anesthesia and to evaluate the efficacy of the training program for anesthesia providers. Methods: This is a preliminary single-center, prospective study. We developed an OSF simulation scenario utilizing evaluation checklists with key actions to manage OSF. The training session comprised four components: orientation, benchmark evaluation (pre-test) according to the checklists, a short didactic lecture, and post-lecture evaluation (post-test). The scenario comprised two steps wherein the participants were supposed to utilize different oxygen supply sources immediately after OSF (Step 1) and minimize the amount of oxygen consumption (Step 2). Results: Fifteen anesthesia providers were enrolled. The score for all anesthesia providers in the post-test was significantly higher than that in the pre-test (median 8 [IQR: 8, 8], 3 [IQR: 3, 4], P < 0.001, respectively). The successful performance rates of all anesthesia providers in one key action of all the four in Step 1 and four of all the six in Step 2 were significantly higher in the post-test than in the pre-test. Conclusions: Our in-situ training method utilizing evaluation checklists for a sudden OSF situation improved overall performance of anesthesia providers.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Efficacy of in-situ simulation training using evaluation checklists for sudden oxygen supply failure during general anesthesia

Kojima

Nishida²,

Watanabe³

2023

Saudi Journal of Anaesthesia

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“…to the supply chain of oxygen, supply chain risks, and environmental impact (Bałys et al, 2021;Bonnet et al, 2021;Botney et al, 2020;Seglenieks et al, 2021;Zhong et al, 2020). The cited works link medical oxygen supply and environmental impact.…”

Section: Medical Gases and Sustainabilitymentioning

confidence: 99%

Life cycle assessment of medical oxygen

Tariq,

Siddhantakar,

Sherman

et al. 2024

Journal of Cleaner Production

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“…An appropriate level of oxygen supply is critical for the regular energy metabolism and signaling transmission in healthy cells [1,2]. The uncontrolled growth of solid tumors will consume a lot of oxygen, and install a hypoxic condition [3,4].…”

Section: Introductionmentioning

confidence: 99%

Intrabody Targeting HIF-1α Mediates Transcriptional Downregulation of Target Genes Related to Solid Tumors

Romão

Vincke

et al. 2021

IJMS

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Uncontrolled growth of solid tumors will result in a hallmark hypoxic condition, whereby the key transcriptional regulator of hypoxia inducible factor-1α (HIF-1α) will be stabilized to activate the transcription of target genes that are responsible for the metabolism, proliferation, and metastasis of tumor cells. Targeting and inhibiting the transcriptional activity of HIF-1 may provide an interesting strategy for cancer therapy. In the present study, an immune library and a synthetic library were constructed for the phage display selection of Nbs against recombinant PAS B domain protein (rPasB) of HIF-1α. After panning and screening, seven different nanobodies (Nbs) were selected, of which five were confirmed via immunoprecipitation to target the native HIF-1α subunit. The inhibitory effect of the selected Nbs on HIF-1 induced activation of target genes has been evaluated after intracellular expression of these Nbs in HeLa cells. The dramatic inhibition of both intrabody formats on the expression of HIF-1-related target genes has been confirmed, which indicated the inhibitory efficacy of selected Nbs on the transcriptional activity of HIF-1.

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Failures of the Oxygen Supply

Cited by 5 publications

References 34 publications

Efficacy of in-situ simulation training using evaluation checklists for sudden oxygen supply failure during general anesthesia

Efficacy of in-situ simulation training using evaluation checklists for sudden oxygen supply failure during general anesthesia

Life cycle assessment of medical oxygen

Intrabody Targeting HIF-1α Mediates Transcriptional Downregulation of Target Genes Related to Solid Tumors

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