This chapter examines higher education institutions' complex obstacles in developing and implementing effective learning outcomes. It emphasizes the need for outcomes that include subject-specific and general skills, meet students' diverse requirements, align with market demands, and incorporate emerging technologies. To facilitate student success in the 21st century, institutions must address these. It examines multidisciplinary programs, technology integration, faculty training, and student participation in outcome formation. It proposes enhancing outcomes through emerging technologies, social and emotional learning, global citizenship education, and entrepreneurship education, emphasizing student-centred approaches. Effective learning outcomes are essential for fostering student success in a constantly changing environment. Case studies from India, the United Kingdom, and the United States provide insights, emphasizing India and lessons from the US and UK experiences.