This country has a big responsibility to the National food fulfillment. Food Estate is a big step taken by the Government to maintain the sustainability of food security in the country as well as a certain step to anticipate the occurrence of a food crisis especially in horticulture sector. Shallot is one of commodity that planted in Food Estate Hortikultura, Humbang Hasundutan Regency. Shallot that infected by the powdery mildew can make a big disadvantage for farmers. This study aims to determine the motivation of farmers and the factors that influenced the motivation of farmers in controlling the powdery mildew on shallot. This research was conducted in Food Estate Hortikultura, Humbang Hasundutan Regency which had aims of developing an integrated and competitive horticultural area, environmentally friendly and modern, encouraging collaboration with stakeholders, and encouraging corporate-based farmer institution. This location was determined purposive. Sampling was done by census that was taking the entire population of shallot farmers in Food Estate Hortikultura. The method of collecting data that used were questionnaires, interviews, and documentation, while the data analysis methods were using Likert scale and multiple linear regression. The research results showed that the motivation level of farmers in controlling the powdery mildew on Shallot was categorized very high which in 84,36%, and the factors that had a very significant effect on farmers' motivation in controlling Powdery mildew on Shallot were the Intensity of Following the Extension, Facilities and Infrastructure, Government Assistance, and Number of Family Dependents.