Faktor yang Memengaruhi Kadar NT-proBNP pada Anak dengan PJB Pirau Kiri ke Kanan yang Mengalami Gagal Jantung

Widyanto, Domiko; Priyatno, Agus; Tamam, Moedrik

doi:10.14238/sp17.3.2015.216-21

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…A 1 g/dL decrease in haemoglobin levels can also increase NT-proBNP levels by 20%. 38 The results of this study showed a significant correlation with the level of weak strength between ferritin levels and NT-ProBNP levels in thalassemia patients at Dr. M. Djamil Padang Hospital (r = 0.399, p = 0.039). These results are in line with the research of Singh et al, which showed a significant correlation between serum NT-proBNP and ferritin levels in thalassemia patients (r = 0.306, p = 0.006).…”

Section: Discussionmentioning

confidence: 57%

Correlation between Ferritin Level and NT-ProBNP in Thalassemia Patient at M. Djamil Hospital Padang

Anugrah,

Hariyanto,

Zatil Izzah

2023

Int J Res Rev

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Background: Thalassemia is a hereditary haemolytic anaemia caused by a genetic defect in the formation of globin chains. Routine blood transfusion is part of the management of thalassemia in Indonesia to maintain haemoglobin levels above the target haemoglobin. The consequence of this therapy is secondary excess of iron (ferritin), which adversely affects cardiac function. NT-pro BNP is one of the cheaper, more accessible, and non-invasive biomarkers that can be used to detect abnormalities in cardiac function. This study aims to analyse the correlation of ferritin levels with NT-proBNP in thalassemia patients. Method: This is an observational analytic study with a cross sectional approach. The inclusion criteria in the study were thalassemia patients who were ≤18 years old and routinely received repeated transfusions. Patients with a history of congenital heart disease, heart failure, hyperthyroidism, overt valvular disease, sepsis, or chronic kidney disease were excluded from this study. Correlation analysis was carried out by analysing the relationship between ferritin levels and NT-proBNP levels in children with thalassemia at RSUP Dr. M Djamil Padang. Result: A total of 27 children were included in this study. The median ferritin level of the samples was 3,465.00 (range 1,100-13,600) ng/ml. The median NT-Pro BNP level of the samples was 4.7767.00 (range 3.503-11.575). The results of the correlation analysis showed a significant positive correlation (p = 0.039) with a weak strength level (r = 0.399) between ferritin levels and NT-ProBNP levels. Conclusion: There is a significant correlation between ferritin levels and NT-proBNP. Keywords: Ferritin, NT-proBNP, Thalassaemia [PDF Full Text]

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Section: Discussionmentioning

confidence: 57%

Correlation between Ferritin Level and NT-ProBNP in Thalassemia Patient at M. Djamil Hospital Padang

Anugrah,

Hariyanto,

Zatil Izzah

2023

Int J Res Rev

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“…One of the symptoms experienced by patients with heart failure and of course the NT-ProBNP is increased. If we look further, this relationship can lead to kidney failure, where the association between heart and kidney failures is quite significant in the presence of anemia [2]. Patients with hypovolemia had the lower NT-proBNP values than patients with euvolemia [7].…”

Section: Resultsmentioning

confidence: 99%

“…NT-proBNP increases due to anemia every 1 g/dL decrease in hemoglobin, and is useful for the diagnosis of heart failure in addition to echocardiography. Furthermore, the acute respiratory infections are also associated with an increase in NT-proBNP [2]. NT-proBNP also helps diagnose heart failure in acute dyspnoe [3].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Background: N terminal pro B type Natriuretic Peptide (NT-proBNP) is an inactive pro-hormone that is used as a biomarker to evaluate our heart's condition. It is secreted due to stretching of venctricles. Increment of NT-proBNP levels usually signifies worse cardiac condition. NT-proBNP has been also used to assess the other indirect conditions that have an impact on cardiomyocytes such as sepsis and dehydration. Objective: NT-proBNP is one of the functional cardiac markers that could be used as one of the markers in critical condition patients to measure cerebral perfusion and venous congestion. The better and the sooner understanding about NT-proBNP could help intensivists for relating with sepsis condition, resuscitation, and volume overload and prevent the multi organ failure. Methods: 30 unconscious intensive care unit (ICU) patients with various sources of infection and sepsis as a working diagnosis from q-SOFA criteria were selected. All of the patients were intubated with mechanical ventilation and oxygenation. The blood sample was taken from the jugular vein to measure NT-proBNP, haemoglobin, procalcitonin and frontal rSO2 are measured by using Near-Infrared Spectroscopy. The collected data include central venous pressure and mean arterial pressure. Results: Significant correlation between NT-proBNP and other markers such as, haemoglobin (p=0.001), right rSO2 (p=0.001), left rSO2 (p=0.001), and mean arterial pressure (p=0.001). NT-proBNP result also has a correlation with procalcitonin (p=0.011) and central venous pressure (p=0.011). Conclusion: NT-proBNP has a correlation with the other markers, such as procalcitonin, as one of the sepsis markers, haemoglobin, mean arterial pressure, and central venous pressure as components of delivery oxygen, and rSO2 as the recent brain oxygenation parameter that has been used. NT-proBNP definitely could be developed in the future as a useful marker in critical condition patients to support the primary organ sepsis patients in the intensive care unit.

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Faktor yang Memengaruhi Kadar NT-proBNP pada Anak dengan PJB Pirau Kiri ke Kanan yang Mengalami Gagal Jantung

Cited by 2 publications

References 3 publications

Correlation between Ferritin Level and NT-ProBNP in Thalassemia Patient at M. Djamil Hospital Padang

Correlation between Ferritin Level and NT-ProBNP in Thalassemia Patient at M. Djamil Hospital Padang

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