Fall-related traumatic brain injury in a Nigerian pediatric population

Balogun, James A.; Koko, Aliyu M; Adebayo, Adegboyega; Aniaku, Ikechukwu; Lasseini, Ali; Balogun, Folusho Mubowale; Uche, Enoch Ogbonnaya

doi:10.1016/j.jocn.2023.01.007

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…TBI is a leading cause of death and disability in patients of all ages [36][37][38][39]. Nowadays, prevention of secondary injury has become an important step in the treatment of TBI [40,41].…”

Section: Discussionmentioning

confidence: 99%

A ROS-responsive loaded desferoxamine (DFO) hydrogel system for traumatic brain injury therapy

Qiu,

Zeng,

Zhang

et al. 2024

Biomed. Mater.

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Traumatic brain injury (TBI) produces excess iron, and increased iron accumulation in the brain leads to lipid peroxidation and reactive oxygen species (ROS), which can exacerbate secondary damage and lead to disability and death. Therefore, inhibition of iron overload and oxidative stress has a significant role in the treatment of TBI. Functionalized hydrogels with iron overload inhibiting ability and of oxidative stress inhibiting ability will greatly contribute to the repair of TBI. Herein, an injectable, post-traumatic microenvironment-responsive, ROS-responsive hydrogel encapsulated with deferrioxamine mesylate (DFO) was developed. The hydrogel is rapidly formed via dynamic covalent bonding between phenylboronic acid grafted hyaluronic acid (HA-PBA) and polyvinyl alcohol (PVA), and phenylboronate bonds are used to respond to and reduce ROS levels in damaged brain tissue to promote neuronal regeneration and recovery. The release of DFO from HA-PBA/PVA hydrogels in response to ROS further promotes neuronal regeneration and recovery by relieving iron overload and thus eradicating ROS. In the Feeney model of Sprague Dawley (SD) rats, HA-PBA/PVA/DFO hydrogel treatment significantly improved the behavior of TBI rats and reduced the area of brain contusion in rats. In addition, HA-PBA/PVA/DFO hydrogel significantly reduced iron overload to reduce ROS and could effectively promote post-traumatic neuronal recovery. Its effects were also explored, and notably, HA-PBA/PVA/DFO hydrogel can reduce iron overload as well as ROS, thus protecting neurons from death. Thus, this injectable, biocompatible and ROS-responsive drug-loaded hydrogel has great potential for the treatment of TBI. This work suggests a novel method for the treatment of secondary brain injury by inhibiting iron overload and the oxidative stress response after TBI.

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Section: Discussionmentioning

confidence: 99%

A ROS-responsive loaded desferoxamine (DFO) hydrogel system for traumatic brain injury therapy

Qiu,

Zeng,

Zhang

et al. 2024

Biomed. Mater.

View full text Add to dashboard Cite

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“…O manejo bem-sucedido do TCE em crianças depende de uma estratégia clínica que envolve avaliação imediata e tratamento multidisciplinar abrangente baseado em evidências para prevenir a mortalidade e reduzir o risco de incapacidade grave, como disfunção neurocognitiva, transtorno convulsivo, incapacidade física e psicossocial. (BALOGUN et al 2023).…”

Section: Fundamentação Teóricaunclassified

“…Embora a etiologia e o padrão dos TCEs sejam multivariados, os acidentes de trânsito e as quedas estão entre as principais causas (BALOGUN et al 2023). É importante que o ambiente para as crianças seja seguro, tomando algumas medidas como reduzir a desordem nos pisos e proteger as crianças de perigos com barreiras, como portões de segurança nas escadas, guardas nas janelas acima do nível do solo e grades de proteção nas camas são medidas de segurança prudentes (HAARBAUER-KRUPA et al, 2019).…”

Section: Fundamentação Teóricaunclassified

Anais Do 2° Congresso Internacional Multiprofissional Em Atenção Primária À Saúde

RIBEIRO DE SOUSA,

MARQUES DAS CHAGAS,

EDUARDO DA SILVA BARBOSA

et al. 2023

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Fall-related traumatic brain injury in a Nigerian pediatric population

Cited by 2 publications

References 30 publications

A ROS-responsive loaded desferoxamine (DFO) hydrogel system for traumatic brain injury therapy

A ROS-responsive loaded desferoxamine (DFO) hydrogel system for traumatic brain injury therapy

Anais Do 2° Congresso Internacional Multiprofissional Em Atenção Primária À Saúde

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