Falling corin and ANP activity levels accelerate development of heart failure and cardiac fibrosis

Gladysheva, Inna P.; Sullivan, Ryan D.; Reed, Guy L.

doi:10.3389/fcvm.2023.1120487

Cited by 7 publications

(1 citation statement)

References 60 publications

(137 reference statements)

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“…Many mechanisms have been proposed to explain this apparent paradox [34,35]. One of them is the impaired activation of prohormone-ANP (pro-ANP) to ANP caused by the decreased levels of corin, a serine protease in the heart that is primarily responsible for the cleavage-activation of pro-ANP [36][37][38]. Another theory involves alterations in the way natriuretic peptide receptors are expressed and activated, along with the components responsible for their downstream signaling.…”

Section: Role Of Natriuretic Peptide Systemmentioning

confidence: 99%

The Importance of Optimal Hydration in Patients with Heart Failure—Not Always Too Much Fluid

Wittczak,

Ślot,

Bielecka-Dabrowa

2023

Biomedicines

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Heart failure (HF) is a leading cause of morbidity and mortality and a major public health problem. Both overhydration and dehydration are non-physiological states of the body that can adversely affect human health. Congestion and residual congestion are common in patients hospitalized for HF and are associated with poor prognosis and high rates of rehospitalization. However, the clinical problem of dehydration is also prevalent in healthcare and community settings and is associated with increased morbidity and mortality. This article provides a comprehensive review of the issue of congestion and dehydration in HF, including HF guidelines, possible causes of dehydration in HF, confirmed and potential new diagnostic methods. In particular, a full database search on the relationship between dehydration and HF was performed and all available evidence in the literature was reviewed. The novel hypothesis of chronic subclinical hypohydration as a modifiable risk factor for HF is also discussed. It is concluded that maintaining euvolemia is the cornerstone of HF management. Physicians have to find a balance between decongestion therapy and the risk of dehydration.

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Section: Role Of Natriuretic Peptide Systemmentioning

confidence: 99%

The Importance of Optimal Hydration in Patients with Heart Failure—Not Always Too Much Fluid

Wittczak,

Ślot,

Bielecka-Dabrowa

2023

Biomedicines

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Deficiencies in corin and atrial natriuretic peptide-mediated signaling impair endochondral ossification in bone development

Zhou,

Mao,

Jiang

et al. 2024

Commun Biol

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Corin is a protease that activates atrial natriuretic peptide (ANP), a hormone in cardiovascular homeostasis. Structurally, ANP is similar to C-type natriuretic peptide (CNP) crucial in bone development. Here, we examine the role of corin and ANP in chondrocyte differentiation and bone formation. We show that in Corin and Nppa (encoding ANP) knockout (KO) mice, chondrocyte differentiation is impaired, resulting in shortened limb long bones. In adult mice, Corin and Nppa deficiency impairs bone density and microarchitecture. Molecular studies in cartilages from newborn Corin and Nppa KO mice and in cultured chondrocytes indicate that corin and ANP act in chondrocytes via cGMP-dependent protein kinase G signaling to inhibit mitogen-activated protein kinase phosphorylation and stimulate glycogen synthase kinase-3β phosphorylation and β-catenin upregulation. These results indicate that corin and ANP signaling regulates chondrocyte differentiation in bone development and homeostasis, suggesting that enhancing ANP signaling may improve bone quality in patients with osteoporosis.

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Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis

2024

N Engl J Med

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Falling corin and ANP activity levels accelerate development of heart failure and cardiac fibrosis

Abstract: RD and Reed GL (2023) Falling corin and ANP activity levels accelerate development of heart failure and cardiac fibrosis.

Cited by 7 publications

References 60 publications

The Importance of Optimal Hydration in Patients with Heart Failure—Not Always Too Much Fluid

The Importance of Optimal Hydration in Patients with Heart Failure—Not Always Too Much Fluid

Deficiencies in corin and atrial natriuretic peptide-mediated signaling impair endochondral ossification in bone development

Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis

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