Intestinal parasitic infections afflict over 3.5 billion individuals globally, leading to an estimated 200,000 deaths annually. Acknowledging variations in susceptibility and outcomes across diverse demographic groups is essential for effective intervention. This chapter provides an in-depth examination of medically significant intestinal parasites, including three protozoa, two nematodes, two cestodes, and one trematode, selected specifically for their primary pathogenesis within the intestines. We offer comprehensive insights into their morphology, pathogenesis mechanisms, and current and emerging diagnostic and therapeutic modalities. By fostering a deeper understanding of intestinal parasitic diseases, this work aims to contribute to the formulation of targeted intervention strategies, ultimately reducing morbidity and mortality associated with these widespread infections.