In this paper, we determine the approximate eigenvalue solution of the non-relativistic wave equation in the presence of the Aharonov-Bohm flux field with Hulthen-Yukawa-Inverse Quadratic potential in a topological defect via point-like global monopole (PGM) geometry. We use the Greene-Aldrich improved approximation scheme into the centrifugal and reciprocal terms appear in the radial Schrödinger equation. We then solve this radial equation using the parametric Nikiforov-Uvarov method and analyze the effects on the eigenvalue solution. We see that the energy levels and the radial wave functions get modified by the topological defect of a point-like global monopole and the magnetic flux field that shows an analogue of the Aharonov-Bohm effect for the bound state. Finally, we utilize the eigenvalue solution to some potential models, such as Hulthen potential, Hulthen plus Yukawa potential, and Hulthen plus inverse quadratic potential and discuss the results.