Fallopian tube epithelial changes in ovarian serous tumors compared with control group: A single-center study

Aslani, Fatemeh Sari; Maleknasab, Mona; Akbarzadeh‐Jahromi, Mojgan

doi:10.4103/nmj.nmj_27_19

Cited by 3 publications

(6 citation statements)

References 22 publications

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“…In 1989, Susan et al found epithelial hyperplasia in 68.7% of 99 cases with serous borderline [28]. While the rate of epithelial hyperplasia was 3% in a study of 200 non-neoplastic cases [4], the rate of cases with epithelial cell line >3 was 1.4% in another overlap [10]. In our study, the rate of cases with epithelial cell sequence ≥3 was 13.05%, and that of papillary hyperplasia was 5.07%.…”

Section: Discussioncontrasting

confidence: 45%

“…In total, 138 women who underwent BTL during S/C were included in this study. The mean age was 34.62 , the mean gravity was 4.89 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), and the mean parity was 3.46 (1-10). In the extended period, which includes the study period (between 15 August 2020 and 31 December 2021), there were 4568 S/Cs, 643 BTLs, and 2 re-anastomoses in our institution.…”

Section: Resultsmentioning

confidence: 99%

“…In the examination of the tubas of 201 patients, 60% of which had total abdominal hysterectomy and bilateral salpingoooferectomy (TAH-BSO), salpingitis was observed in 10.19%, hydrosalpinx in 7.86%, and pyosalpinx in 0.29% [28]. In a study conducted in contrast, salpingitis was observed to be as low as 1.9% in a follow-up of 72 patients after hysterectomy [10]. The salpingitis rate was found to be 7.24% in our study, as opposed to two studies with such different rates.…”

Section: Discussionmentioning

confidence: 99%

“…STILs are lesions that fail to be classified as serous tubal intraepithelial carcinoma (STIC) due to limited proliferation (p53 positive-Ki-67 < 10% or p53 negative Ki-67 > 10%) [8,9]. STICs are associated with nuclear enlargement, a loss of polarity, increased nuclear atypia, abnormal p53 expression, and increased proliferative activity (Ki-67) [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Most of them are bilateral. Low-grade OSC is uncommon (<5% of all ovarian cancers) [10,12]. High and low-grade OSCs are said to have different carcinogenesis origins [13].…”

Section: Introductionmentioning

confidence: 99%

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Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Ömeroğlu,

Ünlü,

Uğur Kılınç

et al. 2023

Medicina

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Background and Objectives: To investigate histopathological changes and serous carcinoma precursors such as secretory cell outgrowths (SCOUTs) and p53 signature in the bilateral tubal ligation (BTL) materials used during cesarean section (S/C). Materials and Methods: In total, 138 patients underwent S/C and tubal sterilization (TS) between October 2020 and May 2021 at Konya City Hospital. Patients’ data were obtained from the hospital’s system. All data and findings were investigated and statistically evaluated. Results: The mean age was 34.62 years (22–44), the mean gravity was 4.89 (2–15) and the mean parity was 3.46 (1–10). In total, 5.79% SCOUT, 7.24% atypia and 9.42% p53 signatures were observed. Significant correlations were shown between the epithelial cell lineage and age between Ki-67, SCOUT, and gravity; between the Ki-67 results and gravity and parity; and between the p53 score and age. Conclusions: TS is a common, safe, and effective method worldwide. Today, BTL is increasing along with increasing S/C ratios. In addition to the reduced risk of ovarian cancers with ligation alone, precursor lesions such as hyperplasia, SCOUT, p53 signature, and STIL/Serous tubal intraepithelial carcinoma (STIC) are encountered in the ampulla materials obtained. Considering the low rates of re-anastomosis, tubal excision may be recommended instead of ligation in women of relatively higher gravity and age.

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Section: Discussioncontrasting

confidence: 45%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Most of them are bilateral. Low-grade OSC is uncommon (<5% of all ovarian cancers) [10,12]. High and low-grade OSCs are said to have different carcinogenesis origins [13].…”

Section: Introductionmentioning

confidence: 99%

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Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Ömeroğlu,

Ünlü,

Uğur Kılınç

et al. 2023

Medicina

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Toward understanding the roles of matrix metallopeptidase 1 in ovarian cancer

Cassie¹,

Isabella²,

Hee³

et al. 2023

J Gynecol Res Obstet

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Ovarian Cancer (OC) is the leading cause of gynecologic cancer-related deaths worldwide. The leading risk factors for OC-related death are OC recurrence and the development of chemotherapy resistance. Investigation into molecular differences that distinguish primary from recurrent disease and the role of the tumor microenvironment (TME) in OC progression may help identify therapeutic targets. Gene expression microarray data comparisons between 21 primary and 21 recurrent OC specimens (16 matched pairs) showed significantly increased expression of Matrix Metallopeptidase 1 (MMP1) in the recurrent specimens (p = 0.03). We, therefore, investigated MMP1 expression regulation and how endogenous and exogenous MMP1 expression influences OC cell proliferation, migration/invasion and chemosensitivity. Both endogenous MMP1 knockdown and low levels of exogenous MMP1 increased cell proliferation of the OC cell line, CAOV2 (p < 0.01 and p < 0.001, respectively). Furthermore, CAOV2 cells cultured with low exogenous MMP1 exhibited increased invasion (p = 0.04 and p = 0.002, respectively, for two shRNA-conditioned mediums, shMMP1-1 or shMMP1-2) and faster migration by wound healing assay relative to controls without MMP1 knockdown. CAOV2 MMP1 knockdown cells were also more resistant than controls to carboplatin (p = 0.04) and paclitaxel (p = 0.017). To explore the functions of cancer environmental MMP1 in different cancer cells, 3 OC cell lines (CAOV2, HEYA8 and SKOV3) were tested for their proliferation when cultured under a low MMP1 conditioned medium. Interestingly, while the proliferation was increased in CAOV2 and HEYA8 cells, it was reduced when SKOV3 OC cells were cultured with low exogenous MMP1 (CAOV2: * p = 0.01, HEYA8: **** p = 0.0004, SKOV3: ** p = 0.002). These results likely reflect inherent MMP1 expression variability in OC tissues and cell lines that is at least partly dependent on other endogenous parameters of the TME, including pH, metabolic state, and oxygenation, all of which were found to alter levels of endogenous MMP1. Given the ability of MMP1 to promote oncogenic or tumor-suppressive behaviors, further study will be necessary to better understand how MMP1 contributes to promoting or restraining tumor progression in an individualized manner.

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Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Ömeroğlu,

Ünlü,

Uğur Kılınç

et al. 2023

Preprint

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Abstract Objectives To investigate histopathological changes and serous carcinoma precursors such as secretory cell outgrowths (SCOUTs) and p53 signature in bilateral tubal ligation (BTL) materials performed during cesarean section (S/C). Materials and Methods 138 patients who underwent S/C and tubal sterilization (TS) between October 2020 and May 2021 at Konya City Hospital. Patients’ data were obtained from the haospital’s system. All data andd findings were investigated and statistically evaluated. Results The mean age was 34.62 years (22 - 44), the mean gravity was 4.89 (2-15) and the mean parity was 3.46 (1-10). 5.79% SCOUT, 7.24% atypia and 9.42% p53 signatures were observed. Significant correlations were shown between epithelial cell lineage and age and between KI-67, SCOUT, and gravity, between KI-67 results and gravity and parity, and between P53 score and age. Conclusion TS is a common, safe, and effective method worldwide. Today, BTL is increasing along with increasing S/C ratios. In addition to the reduced risk of ovarian cancers with ligation alone, precursor lesions such as hyperplasia, SCOUT, p53 signature, and STIL/ Serous tubal intraepithelial carcinoma (STIC) are encountered in the ampulla materials obtained. Considering the low rates of re-anastomosis, tubal excision may be recommended instead of ligation in women of relatively higher gravity and age.

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Fallopian tube epithelial changes in ovarian serous tumors compared with control group: A single-center study

Cited by 3 publications

References 22 publications

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Toward understanding the roles of matrix metallopeptidase 1 in ovarian cancer

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

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