False in Name Only—Gastroduodenal Artery Pseudoaneurysm in a Recurrently Bleeding Patient: Case Report and Literature Review

Binetti, Margherita; Lauro, Augusto; Golfieri, Rita; Vaccari, Samuele; D’Andrea, Vito; Marino, Ignazio R.; Cervellera, Maurizio; Renzulli, Matteo; Tonini, Valeria

doi:10.1007/s10620-019-05853-7

Cited by 9 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To date, all duodenal ulcers with gastroduodenal artery pseudoaneurysms have been reported to occur at the junction between D1 and D2. Sharma described the same pulsating signs [5][6][7] which is consistent with our report. The reason is that the duodenal wall is thin and adjacent to the GDA, particularly at the junction of D1 and D2, which is the closest part, so the main trunk of the GDA is most often destroyed by duodenal ulcer, and pseudoaneurysm may occur subsequently.…”

Section: Discussionsupporting

confidence: 92%

Pulsation of visible vessel or adherent clot in duodenal ulcer may indicate pseudoaneurysm: Case series

Cheng²,

Zhu³

et al. 2023

Medicine

View full text Add to dashboard Cite

Rationale: Owing to the anatomical characteristics of the duodenum, gastroduodenal artery (GDA) pseudoaneurysms can be caused by duodenal ulcers, which may rupture and lead to massive or repeated bleeding. Pseudoaneurysms are usually diagnosed using enhanced computerized tomography or angiography, whereas endoscopic signs have rarely been reported. Patient concerns: Three patients aged 18 to 83 years with bleeding duodenal ulcers and GDA pseudoaneurysms were treated. Diagnosis: All patients had symptoms of gastrointestinal bleeding, and endoscopy revealed duodenal ulcers with visible vessels or adherent clot pulsations. Angiography confirmed the presence of a GDA pseudoaneurysm, which had an adjacent relationship with the duodenum. Interventions: The GDA pseudoaneurysm was embolized in each patient. Outcomes: Through transcatheter arterial embolization, endoscopic treatment, and traditional treatment, hematemesis or melena was gradually stopped and all patients were discharged. Lessons: The pulsation of visible vessels or adherent clots observed during endoscopy in patients with duodenal ulcer may indicate the formation of a gastroduodenal artery pseudoaneurysm. Therefore, we suggest that such patients receive enhanced computerized tomography or angiography to assess whether they need timely endovascular intervention treatment to avoid bleeding caused by a pseudoaneurysm.

show abstract

Section: Discussionsupporting

confidence: 92%

Pulsation of visible vessel or adherent clot in duodenal ulcer may indicate pseudoaneurysm: Case series

Cheng²,

Zhu³

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…They concern the celiac trunk, or superior mesenteric artery, and its branches, especially the splenic artery [ 5 ]. However, the GDA aneurysm is unusual, with an incidence of 0.01-1% of all visceral artery aneurysms; they result clinically in abdominal pain and haematemesis, with a high risk of rupture [ 4 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Depending on the clinical presentation, upper gastrointestinal endoscopy, CT scan, or angiography will be performed, although the CT scan remains the gold standard for early diagnosis and treatment. However, angiography has a better sensitivity (100% versus 67% for a CT scan) and could be diagnostic and therapeutic at the same time [ 4 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pseudoaneurysm of the Gastroduodenal Artery: A Rare Complication of Bile Duct Surgery

Bouhout,

Kharkhach,

Ramdani

et al. 2024

Cureus

View full text Add to dashboard Cite

Pseudoaneurysm of the gastroduodenal artery (GDA) is an exceptional complication of common bile duct (CBD) resection. We present the case of a 60-year-old woman with a history of cholecystectomy. The patient was admitted to our hospital for surgical management of the cystic dilatation of the CBD. The patient presented on postoperative day 21 with hemodynamic instability related to a pseudoaneurysm of the GDA. An urgent open surgery was performed with dissection and ligation of the GDA.

show abstract

“…Existing studies have shown that different visceral pain information can be transmitted to the gray matter of the spinal cord, and then projected to higher central nervous nuclei, such as thalamus, nucleus of the solitary tract, parabrachial nucleus, midbrain periaqueductal gray matter, anterior cingulate cortex, limbic system, basal nucleus, amygdala, hypothalamus, etc. ( 9 - 11 ). Pancreatic cancer visceral pain has not received much attention, and only a few studies have shown that it was related to peripheral afferent nerve infiltration.…”

Section: Introductionmentioning

confidence: 99%

Glutamatergic neurons in the paraventricular nucleus of the hypothalamus participate in the regulation of visceral pain induced by pancreatic cancer in mice

Ji,

Cao,

Song

et al. 2024

Hepatobiliary Surg Nutr

View full text Add to dashboard Cite

Background Visceral pain induced by pancreatic cancer seriously affects patients’ quality of life, and there is no effective treatment, because the mechanism of its neural circuit is unknown. Therefore, the aim of this study is to explore the main neural circuit mechanism regulating visceral pain induced by pancreatic cancer in mice. Methods The mouse model of pancreatic cancer visceral pain was established on C57BL/6N mice by pancreatic injection of mPAKPC-luc cells. Abdominal mechanical hyperalgesia and hunch score were performed to assess visceral pain; the pseudorabies virus (PRV) was used to identify the brain regions innervating the pancreas; the c-fos co-labeling method was used to ascertain the types of activated neurons; in vitro electrophysiological patch-clamp technique was used to record the electrophysiological activity of specific neurons; the calcium imaging technique was used to determine the calcium activity of specific neurons; specific neuron destruction and chemogenetics methods were used to explore whether specific neurons were involved in visceral pain induced by pancreatic cancer. Results The PRV injected into the pancreas was detected in the paraventricular nucleus of the hypothalamus (PVN). Immunofluorescence staining showed that the majority of c-fos were co-labeled with glutamatergic neurons in the PVN. In vitro electrophysiological results showed that the firing frequency of glutamatergic neurons in the PVN was increased. The calcium imaging results showed that the calcium activity of glutamatergic neurons in the PVN was enhanced. Both specific destruction of glutamatergic neurons and chemogenetics inhibition of glutamatergic neurons in the PVN alleviated visceral pain induced by pancreatic cancer. Conclusions Glutamatergic neurons in the PVN participate in the regulation of visceral pain induced by pancreatic cancer in mice, providing new insights for the discovery of effective targets for the treatment of pancreatic cancer visceral pain.

show abstract

False in Name Only—Gastroduodenal Artery Pseudoaneurysm in a Recurrently Bleeding Patient: Case Report and Literature Review

Abstract: § Renzulli M. and Tonini V. equally contributed as joint senior Authors.

Cited by 9 publications

References 35 publications

Pulsation of visible vessel or adherent clot in duodenal ulcer may indicate pseudoaneurysm: Case series

Pulsation of visible vessel or adherent clot in duodenal ulcer may indicate pseudoaneurysm: Case series

Pseudoaneurysm of the Gastroduodenal Artery: A Rare Complication of Bile Duct Surgery

Glutamatergic neurons in the paraventricular nucleus of the hypothalamus participate in the regulation of visceral pain induced by pancreatic cancer in mice

Contact Info

Product

Resources

About